该【自身免疫研究生 】是由【小落意心冢】上传分享,文档一共【65】页,该文档可以免费在线阅读,需要了解更多关于【自身免疫研究生 】的内容,可以使用淘豆网的站内搜索功能,选择自己适合的文档,以下文字是截取该文章内的部分文字,如需要获得完整电子版,请下载此文档到您的设备,方便您编辑和打印。自身免疫研究生SelftoleranceandAutoimmunityPartIicmechanismsofselftoleranceandautoimmunityGOALOFTHEIMMUNESYSTEMSeparateselffromnon-selfStayinharmonywithselfantigensandtissuesofthehostV(D)binationassemblesuniqueBCRandTCRgenesfromthreeseparategenesegments,thevariable(V),diversity(D)andjoining(J)genes,duringB-andT-(suchasthespleen,lymphnodesandtonsils).Between20and50%ofTCRsandBCRsgeneratedbyV(D)?8%:thefailuretomountanimmuneresponsetoselfantigens(endogenousantigens)-Note:failure=/=passivity;toleranceisactiveImmunologicallyspecific(.,specificepitopes)Learnedoracquired(.,activeprocess)ImmatureordevelopinglymphocytesmoresusceptibletotoleranceinductionthanmaturelymphocytesInadequatestimulationofmaturecellscanleadtotolerancePrimarilyafunctionofTcells;howeverBcellscanbetolerizedTcelltolerance:longlived,requireslessAgstimulationBcelltolerance:shorterlived,requiresmoreantigenCHARACTERISTICSofTOLERANCE(5)Deathanddeletionofsemi--peptide?binationstriggerthedeath(negativeselection)(AIRE)geneZAP70(?-chain-associatedproteinkinaseof70kDa)GRB2(growth-factor-receptor-boundprotein2)MINK(misshapen-Nck-interactingkinase(NIK)relatedkinase)prolongedp38andJNK(Junkinase)activationBIMNur77familyoforphannuclearreceptorsbinationofstrongstimulatorysignalsthroughTCRandCD28is,paradoxically,apotenttriggerofnuclearfactor-B(NF-kB)activation.
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