MRSA感染的抗菌治疗.ppt

该【MRSA感染的抗菌治疗 】是由【小可爱】上传分享，文档一共【48】页，该文档可以免费在线阅读，需要了解更多关于【MRSA感染的抗菌治疗 】的内容，可以使用淘豆网的站内搜索功能，选择自己适合的文档，以下文字是截取该文章内的部分文字，如需要获得完整电子版，请下载此文档到您的设备，方便您编辑和打印。;42:S65--acquiredinfectionPenicillinase-producingSaureus02550751001940196019802000YearResistantisolates(%)Methicillin-resistantSaureus02550751001940196019802000YearResistantisolates(%)Progressionofresistantusaureusialinfectionscausedbyantimicrobial-resistantSaureusisolatesmunity-acquiredinfectionsDate2EmergenceofresistantpathogensialSaureusbacteremiapredominantlyduetotheincreaseinMRSAintheUKWyllieD,;333:281-,UK;MSSA=methicillin-usaureusaPer100,000admissions;bP<.01;cP>.*Year4005003001501005020192019200020192019201920192019CasesofSaureusBacteremiaaialSaureusBacteremiabYear4005003002001501005020192019200020192019201920192019CasesofSaureusBacteremia*Year4005003002001501005020192019200020192019201920192019CasesofSaureusBacteremiaaMSSAMRSAcbDate3*Date4HA-MRSAStrainsHighlocalprevalenceHistoryofMRSAinfectionorcolonizationClosecontactwithinfectedindividualExtendedhospitalizationResidentofnursinghomeorlong-term-carefacilityInvasivedevicesDialysisCatheterizationEnteralfeedingRecentantibioticuseRiskfactorsforinfectionwithMRSACA-MRSAStrainsHighlocalprevalenceHistoryofMRSAinfectionorcolonizationClosecontactwithinfectedindividualCrowdedand/orunsanitaryconditionsPrisonMilitarycampDepressedimmunesystemParticipationincontactsportsSharingathleticequipment/:mayoclinic/health/mrsa/DS00735/DSECTION=,;49:999-,;136:834-,;355:666-,3延长住院时间2,3增加住院费用1,2,,;5:9-;44(supplA):31-;23:106-;20:408-;36:53-:MRSAvsMSSA比值比研究MSSA:methicillin-usaureusDate7*Date8*Date9近30余年来,MRSA不断增加,万古霉素成为治疗MRSA的代表性药物。虽然80’出现另一种糖肽类药物替考拉宁,但万古霉素似乎仍是治疗MRSA的主流品种。而且随着制剂进一步纯化,从“MississippiMud”到很高纯度的白色粉末,消除了耳毒性。除非与AMG联合使用,肾毒性很少出现。万古霉素经历的辉煌:抗MRSA的经典药物!Date15