北京协和医学院基础医学院药理学系.pptx

该【北京协和医学院基础医学院药理学系 】是由【小屁孩】上传分享，文档一共【42】页，该文档可以免费在线阅读，需要了解更多关于【北京协和医学院基础医学院药理学系 】的内容，可以使用淘豆网的站内搜索功能，选择自己适合的文档，以下文字是截取该文章内的部分文字，如需要获得完整电子版，请下载此文档到您的设备，方便您编辑和打印。镇痛药Analgesics北京协和医学院基础医学院药理学系叶菜英2021/10/101镇痛药AnalgesicsS,eliminateoreasepainselectively,tolessenthenervousofpatients,theseagentsrelievepainwithoutproducingalossofconsciousness。。In1806,MorphinewasfirstisolatedfromthejuiceoftheopiumpoppybyGermanpharmacistFriedrichSertürner;Duringthe1950s,aseriesofmorphine-likepotentanalgesicsweresynthesized,suchaspethidine,methadone,etorphine,,anismsufferthenociceptivestimulus;Painisalsothebasisforthedoctorsdiagnosingdiseases。panyanxiety,dread,horror,fortandsoon,tocausethepatientsdisorder,evenshock。Acutepainthathasbeenmadeadefinitediagnosis,shoulduseanalgesicsimmediately;Butitisinadvisabletousenarcoticanalgesicswhenapainhasn`tbecertified,:chemicalconstitutionaffinityandintrinsicactivityAgonists:morphine,Pethidine,adanton……Antagonists:Naloxone,NaltrexonePartialagonist:Pentazocine,NalorphinePhysiologicaldisposition:takeorally,injection→passthroughthebloodbrainbarrier→hepaticmetabolism→renalexcretion2021/10/105HOHOONCH3吗啡morphine阿片(opium)生物碱类(opiatealkaloids)Morphine(1806,10%ofopiumtotalbase)Codeine(1832,methyl-morphine)Heroin(1874,acetomorphine,powerfuladdictivedrugs)PhenanthreneIsoquinolinePapaverine2021/10/106阿片生物碱类镇痛药阿片生物碱类***(poppy)2021/10/107FreshcapsuleofopiumpoppyCutcapsuleshowinglatexexudingfromcut2021/10/108镇痛药阿片生物碱类***(poppy)2021/10/109镇痛药阿片生物碱类含阿片生物碱类植物:***2021/10/1010