造血干细胞移植后抽搐原因分析.ppt

造血干细胞移植后抽搐原因分析
HSCT后引起抽搐的可能的病因
S感染(HHV6、EBV、弓形虫、曲霉菌等)
电解质紊乱(低钠血症(SIADH)、低血糖等)
药物因素(CSA、BU、FK506等)
中枢神经系统PTLD
S白血病
高血压
血栓性微血管病
plications after Allogeneic Hematopoietic Stem Cell Transplantation in Children: Analysis of Prognostic Factors
期刊:Biol Blood Marrow Transplant (2015)
作者:Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
结果及结论:
383例,S并发症,73次抽搐(移植后+400天里有 20%S并发症)
其中,63%发生在移植后+100天内
粒细胞植入时间、广泛的cGVHD、S并发症患儿死亡的独立危险因素
然而,S并发症者之间是没有差距的(% VS %,P=)
calcineurin inhibitor (CNI)-rerelated neurotoxicity, which presented PRES and/or toxic encephalopathy with symmetrically reduced diffusion in the periventricular and supraventricular white matter in brain ic resonance imaging diffusionfindings without any definite etiologies
Epileptic seizures in patients following allogeneic  hematopoietic stem cell transplantation: a retrospective analysis of incidence, risk factors, and survival rates
期刊:Clinical Transplantation
作者:北大人民医院,黄晓军
结果及结论:
1461例移植患者,%发生抽搐
其中79例抽搐患者中,%(42例)死亡
抽搐发生时间:3例(%)预处理阶段,
52例(%)移植后+100天内,
20例(%)移植后后+100天至1年内,
4例(%)移植1年后
独立危险因素包括:受者年龄<18岁、移植物类型、aGVHD、低钠
1年存活率:% VS %
:% VS %
Diagnostic and therapeutic implications of plications following paediatric haematopoietic stem cell transplantation
期刊:Bone Marrow Transplant. 2008 Feb
作者:Department of Paediatric Oncology, Haematology and Clinical Immunology, Heinrich-Heine University Medical Centre, Düsseldorf, Germany
结果及结论:
165例儿童,24%S并发症
发生在移植后+22至+91天
感染(10例),药物毒性(5例),脑血管事件(2例),CNS复发(2例)
Etiology, characteristics and e of seizures after pediatric hematopoietic stem cell transplantation
期刊:Seizure, 2014, 23(2):140-5
作者:University of Bologna, S. Orsola Malpighi Hospital, Italy
结果及结论:
261例移植,28例发生抽搐,
其中PRES S infection 4例
5年OS: %,%
非肿瘤性疾病及脐血造血干细胞移植是抽搐的独立危险因素