部分析因试验设计优化α-氯代十二酸合成工艺-南京工业大学学报.doc

部分析因实验设计优化α-***代十二酸合成工艺
丘宝增1 , 胡静怡2 , 汤吉海1 , 杨运2 , 陈献1 , 费兆阳1 , 乔旭1 , 崔咪芬1
(1. 南京工业大学化学化工学院,江苏南京,210009;
2. 江苏省东泰精细化工有限责任公司,江苏镇江,212132)
摘要:采用5因素2水平的部分析因实验对十二酸***化合成α-***代十二酸的工艺进行优化,方差分析得到了反应温度、反应时间、催化剂用量、Cl2流量和O2流量及其交互作用的统计重要度。通过线性模型回归和响应曲面分析了各因素对α-***代十二酸收率的影响规律,获得浓硫酸催化合成α-***代十二酸的最佳实验条件为:十二酸20 g,反应温度135 ℃,反应3 h,催化剂用量为10%,Cl2流量为100 mL/min,O2流量为50 mL/min。在最优条件下,α-***%。
关键词:十二酸;α-***代十二酸;实验设计;部分析因;优化
中图分类号: 文献标志码:A 文章编号:1671-7627
Optimization of synthesis of α-chlorododecanoic acid using by fractional factorial design
QIU Baozeng1, HU Jingyi2, TANG Jinghai1, YANG Yun2, CHEN Xian1, FEI Zhaoyang1, QIAO Xu1, CUI Mifen1,
(1. College of Chemistry and Chemical Engineering, Nanjing Tech University, Nanjing, 210009, China;
2. Jiangsu Dongtai Fine Chemical Co. Ltd. Zhengjiang, 212132, China)
Abstract: Synthesis process of α-chlorododecanoic acid (α-CDA) through chlorination of dodecanoic acid (DA) was optimized investigated by the fractional factorial design (FFD) of 5 factors and 2 levels. Statistical importance of reaction temperature, reaction time, catalyst amount, O2 and Cl2 flow rates and their interaction was analyzed, respectively. Furthermore, tThe effect laws of every factor to the yield of α-CDA were obtained by linear regression model and analyzed through response surface. The rResults showed that the optimized DA chlorination conditions using concentrated s