洛铂联合香菇多糖治疗恶性胸腔积液临床观察.doc

洛钳联合香菇多糖治疗恶性胸腔积液临床观察【摘要】目的:观察胸腔内置管注入洛钳和香菇多糖治疗恶性胸腔积液的疗效。方法:收治恶性胸腔积液60例,随机数字表法分为两组,经皮胸腔内置管引流尽胸液后,治疗组30例予胸腔内注入洛钳50mg+香菇多糖4mg,对照组30例予顺钳40mg/m2注入胸腔。结果:治疗组总有效率和生活质量改善率均优于対照组(P〈)。两组毒副作用相近。结论:洛钳联合香菇多糖胸腔内化疗治疗恶性胸腔积液安全冇效。【关键词】洛钳;顺钳;香菇多糖;恶性胸腔积液[Abstract]Objective::60patientswithmalignantpleuraleffusionweredividedintotwogroups,percutaneousintrathoracicdrainagetopleuraleffusion, 30casesinthetreatmentgroupweretreatedwithintrapleuralinjectionoflobaplatin50mg+lentinan4mg,30casesinthecontrolgrouptreatedwithcisplatin40mg/:Thetotaleffectiverateandtheimprovementrateoflifequalitywasbetterthanthatofthecontrolgroup,withsignificantdifferences(P<)•:harideperfusionissafeandeffectiveinthetreatmentofmalignantpleuraleffusion,operationisconvenient,effective,1essadversereactions,especiallysuitableforpatientswithadvancedcancerthroughmultipleplatinumchemotherapywithpleuraleffusion.【Keywords】Lobaplatin;Cisplatin;Lentinan;MalignantpleuraleffusionFirst-author?saddress: JingmenHospitaiofTraditionalChineseMedicineofHubeiProvinceOncology,Jingmen448000,Chinadoi:.1674-,多为晚期肿瘤患者,该类患者胸腔积液生长迅速,常出现胸闷、胸痛、呼吸困难等症状,严重影响患者的生活质量,若不予治疗,生存期短[1]。目前常用的治疗方法为胸腔内注入顺钳等抗肿瘤药物,顺钳为近年来最常用的胸腔内灌注化疗药物Z一,其主要作用机制为影响肿瘤细胞DNA的合成及复制,能有效抑制或杀灭肿瘤细胞,刺激胸膜细胞增殖和纤维化,促进胸腔积液吸收,阻止胸腔积