生物可降解羧甲基壳聚糖聚乳酸水凝胶药物释放研究.pdf

生物可降解羧***壳聚糖一聚乳酸水凝胶的药物释放研究 CMCS上,DSC测试表明EDC/NHS有效地交联了CMCS、。随着 EDC/NHS用量的增加,体系中氨基数目减少,说明交联度随之增加。TGA曲线中 CMCS-PLA与CMCS—,说明PTX的加入没有改变水凝胶材料的热稳定性,载药水凝胶材料及药物可以稳定地存在于生理环境的条件下。在对 CMCS·PTX、CMCS-PLA-PTX进行药物释放行为研究中,通过改变溶胀溶液类型, 测定不同环境对药物释放速率的影响,实验探究表明,经PBS溶液溶胀的载药水凝胶的药物释放速率较经溶菌酶溶液溶胀的载药水凝胶快。关键词:羧***壳聚糖聚乳酸紫杉醇载药水凝胶药物释放万方数据青岛科技大学研究生学位论文 B10DEGRADABLE CARBOXYMETHⅥ, CHll℃SAN—POIYLACTIC AC【D HYDRO(拒LS FOR CONTROLLED DRUG RELEAsE ABSTACT Carboxymethyl chitosan(CMCS)is obtained from carboxymethylation of chitosan,the second haride theoutstanding properties ofchitosan such aS patibility,biodegradability,and biological contrast to chitosan with high degree ofcrystallinity and poor water solubility due tostrong hydrogen bonding,CMCS iseasily water solubleand hasbeen widely used for applications in many fieldssuch as medicine,pharmacology, agriculture,health careand macromolecules contain numerous amino and carboxyl groups,which allows chemical modification ofCMCS by attachment of other molecules,thus improving thephysico-chemical and mechanical properties of CMCS. Polylactic acid(PLA)is a biodegradable synthetic polymer with good patibility,mechanical properties,and degradation iswidely used forvarious biomedical applications such as surgical sutures,artificial bone,drug carrier,tissuerepair andregeneration ,PLA ishighlycrystalline and hydrophobic,which greatly limitsitsapplications intissueengineering and drug of PLA onto thecarboxymethyl chitosan backbone shouM allow to conbine the properties of ponents, including patibility, biodegradability,biological activity and mechanical ,the resulting graRed copolymers are amphiphilic with bothhydrophilic and hydrophobic domains. which presents great interest fordrug releaseapplications. Paclitaxel(PTX)is one ofthemost monly used for the treatment ofbreast,cancel ovarian cancel lung cancer, PTX ispoorly 万方数据生物可降解羧