国外大学细胞生物学课件 英文课件15.ppt

D103 - Cell Biology - lecture 15 ? 2011 Grant MacGregor & Christine S ü tterlin – All rights reserved Page 1 Lecture 15 – Signaling II Introduction to signaling (contd) Steroid, thyroid, vitamin D, retinoid hormone signaling Principles, part II ? binations of signals can elicit different responses. ? Concept of protein “ domains ” - prised of a series of conserved amino acids, which have specific functional properties and are shared between many different proteins. ? Signaling processes can mediate a rapid or delayed response. ? Steroid , thyroid, vitamin D, retinoid hormone signaling. mended Reading: MBOC 5e, pages 175 - 190, 879 - 904 D103 - Cell Biology - lecture 15 ? 2011 Grant MacGregor & Christine S ü tterlin – All rights reserved Page 2 ponents of a simple generic extracellular signaling pathway stimulus receptor transduction effector response(s) D103 - Cell Biology - lecture 15 ? 2011 Grant MacGregor & Christine S ü tterlin – All rights reserved Page 3 Cells (like humans) respond in discrete ways to different combinations of signals Note - almost all cells require constant stimulation to remain alive. We'll revisit this issue later during control of apoptosis. c-maj c-min humans too ! D103 - Cell Biology - lecture 15 ? 2011 Grant MacGregor & Christine S ü tterlin – All rights reserved Page parison of the primary amino acid sequence of different proteins from plants, protists and animals reveals the existence of regions of conserved amino acids that usually constitute functional domains – . “ WW ” domain ID # of different proteins WW PIN1 TCRG1 IQGAP1 DRE4 WBP4 FCA Prp40 URN1 Fbp11 D103 - Cell Biology - lecture 15 ? 2011 Grant MacGregor & Christine S ü tterlin – All rights reserved Conserved modular domains are found in a wide range of proteins where each domain performs a similar function Page 5 domain binds to modified peptide oligo-peptide, DNA, RNA homodimerization phospholip