国外大学细胞生物学课件 英文课件18.ppt

Page 1 D103 - Cell Biology - lecture 18 ? 2011 Grant MacGregor & Christine S ü tterlin - all rights reserved ? General background on cell surface receptors with intrinsic or associated kinase activity . ? Examples of different ways in which cell surface transmembrane receptors can be activated . ? Illustration of principles - three different classes of cell surface receptors that have either intrinsic or associated kinase activity, plus their downstream effectors - Receptor Transduction signaling proteins ? TGF ?-family receptors Smads ? Cytokine receptors JAK's / STAT's ? Receptor tyrosine kinasesRas / MAP kinase ? Examples of diseases associated with defects in these pathways. Lecture 18 – Signaling V Cell Surface Receptors with Intrinsic or Associated Kinase Activity mended Reading: MBOC 5e, pages 921 - 945 Page 2 D103 - Cell Biology - lecture 18 ? 2011 Grant MacGregor & Christine S ü tterlin - all rights reserved ? Receptor tyrosine kinases - have intrinsic kinase activity; phosphorylate specific tyrosine (Y) residues on a small set of intracellular signaling proteins. ? Tyrosine-kinase associated receptors - these cell surface receptors don't have intrinsic kinase activity, but instead they associate with proteins that have such activity. ? Receptor serine / threonine kinases - have intrinsic kinase activity; phosphorylate specific serine (S) or threonine (T) residues on intracellular signaling proteins. ?‘ Receptor-like ’ tyrosine phosphatases - remove phosphate groups from tyrosines. Termed ‘ receptor-like ’ because no ligand has to date been found for these proteins. ? Receptor guanylylcyclases - directly catalyze synthesis of cGMP in cytosol. There are five major classes of enzyme-linked cell surface receptors sixteen classes of receptors with discrete mechanisms of signal transduction Page 3 D103 - Cell Biology - lecture 18 ? 2011 Grant MacGregor & Christine S ü tterlin - all rights reserved Cell Surface Rece