国外大学细胞生物学课件 英文课件26.ppt

D103 - Cell Biology - lecture 25 ? 2011 Grant MacGregor & Christine S ü tterlin – All rights reserved Page 1 Lecture 25 – Apoptosis; aka Programmed cell death ? Apoptosis - a regulated form of cell death . ? Cytology of apoptosis. ? Differences between apoptosis and necrosis. ? Functions for apoptosis in development and homeostasis. ? Common disease states are associated with an imbalance in apoptosis. ? Apoptosis can be initiated by signals from inside or outside the cell. ? Growth factors and cell adhesion promote cell survival via suppression of apoptosis. Advice regarding preparation for final exam ? Review your lecture notes thoroughly- use your study groups ! ? If necessary, use the textbook as a cross-reference to clarify the lecture notes. ? Focus on understanding concepts and principles . ? Review old exams and iClicker questions – available soon on class website ? TA's will offer review session = see Class Messageboard for details ? BioPeer Tutors may offer review session = TBA mended Reading: MBOC 5e, pages 1115 - 1129 D103 - Cell Biology - lecture 25 ? 2011 Grant MacGregor & Christine S ü tterlin – All rights reserved Page 2 Apoptosis - a regulated form of cell death ? There is massive turnover of cells within the healthy human body. ? Each hour, millions of normal cells die within the gut and bone marrow. ? These cells are replaced by new cells via mitosis fromsmall populations of stem cells. ? Controlled cell death has a critical function in balancing overall numbers of cells, both during embryonic development and in post-natal life. ? Apoptosis is a term used to describe normal process of cell death that occurs during development orin homeostasis ans. ? Apoptosis and programmed cell death can be considered synonymous and are often used interchangeably. ? The term apoptosis is derived from Greek ( apo = from, tosis = falling), with the allusion that normal cell death is similar to natural death asso