内皮细胞损伤、血小板活化及功能状态与2型糖尿病的相关性.doc

1 内皮细胞损伤、血小板活化及功能状态与 2 型糖尿病的相关性【关键词】内皮损伤 Correlation between vascular endothelial cell injury, platelet activation and functional status in type 2 diabetes 【 Abstract 】 AIM: To investigate the vascular endothelial cell injury and the platelet activation and functional status change in type 2 diabetes patients. METHODS: The plasma levels of von willebrand factor ∶ antigen (vWF ∶ Ag) and granule membrane protEin140 ( GMP140 ) were measured by double sandwich ELISA. The adhesiveness of platelet was determined by Salzmans method. RESULTS: The plasma levels of vWF ∶ Ag ( ± )%, GMP140 ( ± )μ g/L and PAdT ( ± )% of type 2 diabetes were significantly higher than those of normal controls ( ); The plasma levels of these markers in the group of type 2 diabetes with plication were higher than those in the one without plication ( ); plasma levels of GMP140 and PAdT were 2 positively correlated with those of vWF ∶ Ag [( ± )%, ( ± )μ g/L ,( ± )% , r=, , ]. CONCLUSION: Type 2 diabetes can cause vascular endothelial cell injury, platelet activation and functional status change. The plasma levels of vWF ∶ Ag, GMP140 and PAdT may reflect vascular pathological changes in type 2 diabetes patients toa certain extent. 【 Keywords 】 diabetes ; endothelial cell injury ; platelet activation ; angiopathies 【摘要】目的: 观察 2 型