金樱子醇提物对血清病型肾炎大鼠的药理作用.doc

金樱子醇提物对血清病型肾炎大鼠的药理作用.doc金樱子醇提物对血清病型肾炎大鼠的药理作用
【关键词】金樱子;,,血清病型肾炎;,,药理作用
摘要:目的研究金樱子醇提物对血清病型肾炎大鼠的药理作用。方法经大鼠尾静脉注射小牛血清诱发血清病型肾炎,对血清病型肾炎大鼠灌胃给予金樱子醇提物4周,观察金樱子醇提物对血清病型肾炎大鼠的尿肌酐、尿蛋白及血清总蛋白、肌酐和尿素氮的作用。结果金樱子醇提物显著降低血清病型肾炎模型大鼠尿蛋白、血清肌酐和尿素氮水平,升高血清总蛋白含量,减轻肾组织的病理变化。结论金樱子醇提物能减轻血清病型肾炎大鼠模型肾小球病变并改善肾功能。
关键词:金樱子; 血清病型肾炎; 药理作用
Effect of Jinyingzi on the Acute Experimantal Serum Sickness Nephritis in Rats
Abstract:ObjectiveTo study the pharmacological actions of Jinyingzi on acute experimental serum sickness nephritis model The rat model of acute experimental serum sickness nephritis through caudal renal function about urinary protEIn、serum total protein、creatinine and urinary nitrogen in model rat arkably reduced urinary protein、levels of serum creatinine and urinary nitrogen,increased serum total protein content,and alleviated the pathological injury in model can lessen pathological changes of glomerulus in acute experimental serum sickness nephritis model rats, ameliorate their renal function.
Key ental serum sickness nephritis model; Pharmacoligical actions

金樱子是蔷薇科蔷薇属植物金樱子Rosa laevigata ,在广西各地均有分布,性味酸、甘、平,归肾、膀胱、大肠经,具固精缩尿、涩肠止泻功能。作者曾用被动型Heymann肾炎大鼠模型对金樱子进行过研究[1]。为更全面了解金樱子对肾炎的药理作用,进一步采用血清病型肾炎大鼠模型研究金樱子醇提物的药理作用。现将结果报道如下。
1 材料
药品与试剂金樱子,购自南宁医药有限公司中药饮片厂,批号:03050426,经本所中药室鉴定。金樱子醇提物为75%乙醇提取浓缩稠膏,实验时用1%羧***纤维素钠溶液配成所需剂量。雷公藤多苷片,浙江得恩海制药有限公司生产,批号:200201402。总蛋白Douma