(发育生物学）VIII 干细胞生物学.ppt

Developmental Biology
Chapter 8: Stem cell biology
More than 200 clearly recognizable differentiated cell types
in mammals
The fertilized eggs in development undergo essive cell differentiation, forming a variety of different cell lineages
Hypodermis: 皮下组织, Coelomocyte: 体腔细胞
Stem cells can be identified during the essive differentiation of different cell lineages in development
Concept of stem cells in the context of development
Stem cells are defined as a cell population that has the capacity both to self-renew and to give rise to at least one kind of nondividing, fully differentiated descendant.
Stem cells can be identified during the essive differentiation of different cell lineages in development, thus, are classified based on their developmental potential, developmental stages etc
The stem cell classification—developmental potential
Totipotent(全能干细胞):
Ability of a single cell to divide and produce all the differentiated cells in anism, including extraembryonic tissues
- Examples: the fertilized egg, blastomeres of early morulas
Pluripotent (多潜能干细胞):
Potential of a cell to generate all cell types except extraembryonic tissue
- Examples: embryonic stem cells and induced pluripotent stem (ips) cells
Multipotent (多能干细胞):
Potential of a cell to form several lineages within a tissue
- Examples: Haematopoietic stem cells
Unipotent (单能干细胞):
Potential of a cell to form a single lineage within a tissue
- Examples: Epidermal stem cells
The stem cell classification—developmental stages
Early Development
Embryonic stem cells (ESc)
Germline stem cells (GSC)
Induced pluripotent stem cells (iPSCs)
The germ layer derived development
Ectoderm
Neural stem cells
Epidermal stem cells
Mesoderm
Hematopoietic stem cells
Mesenchymal stem cells
Endoderm
Liver stem cells
Pancreatic stem cells
Stem cells in the epithelium of the small intestine and colon
Stem cell biology
1 Introduction
2 Early Development
Embryonic stem cells (ESc)