脑梗塞患者中颈动脉粥样硬化斑块性质影响因素探讨.docx

华中科技大学硕士学位论文
脑梗塞患者中颈动脉粥样硬化斑块性质影响因素探讨
彭涛
导师:唐荣华教授
华中科技大学同济医学院附属同济医院神经内科
摘要
目的:根据颈动脉粥样硬化斑块性质的不同,探讨各种导致颈动脉粥样硬化
的危险因素在动脉粥样硬化斑块形成上的影响。
方法:采用回顾性研究方法,对同济医院神经内科 305 例脑梗塞患者(2010
年 1 月-2012 年 1 月)的临床资料进行统计学分析,根据患者颈动脉超声波回声
强度的不同分为高回声组、低回声组、混合回声组、无斑块组,应用方差分析的
统计方法,统计各种因子在各组之间的差异,探讨各种因子在颈动脉粥样硬化斑
块形成上的影响。
结果:①高纤维蛋白原、高 HCY、高 FBS 可能是导致动脉粥样硬化斑块形成
的危险因素,但是在各组之间无统计学差异;②高龄和高 Hs-CRP 可能是导致高
回声和混合回声斑块的危险因素;③女性可能是导致高回声斑块形成的一个危险
因素;④高血小板、低 TC、高 TG、低 LDL 可能是导致低回声斑块的危险因素;
⑤低 HDL 水平可能是导致低回声斑块和混合斑块形成的一个危险因素。
结论:性别、年龄、血小板、TC、TG、HDL、LDL、Hs-CRP 均是影响动脉粥
样硬化斑块性质的危险因素。
关键词:脑梗塞、动脉粥样硬化斑块、危险因素、回顾性研究
2
华中科技大学硕士学位论文
An analysis of Carotid atherosclerotic
plaque with impact factors in patients with
cerebral infarction
(Department of neurology, Tongji Hospital Affiliated with Tongji Medical College,
Huazhong University of Science and Technology, wuhan,430030)
Postgraduate Candidate: Peng tao
Tutor: Prof. Tang ronghua
Abstract
Purpose:

Depending on the nature of carotid artery atherosclerotic plaque,
studying a variety of risk factors leads to carotid artery atherosclerosis in the
atherosclerotic plaque formation.
Method: Have retrospectively explored analysed the clinical data of 305 cases of
patients with cerebral infraction (2010 January to 2012 January) in department of
neurology. Depending on the carotid ultrasound echo intensity, those patients were
divided into high-echo group, low-echo group, mixed-echo group, non-plate group.
Adopting the application of analysis of variance statistic a variety of factor in the
difference between the groups mentioned, to explore the influence of various factors
on the carotid artery atherosclerotic plaque formation.
Result: 1.

High fibrinogen, high HCY, high FBS maybe have contributed to the
atherosclerotic plaque formation, but there were no significant difference between the
groups. 2. Agedness and hs-CRP maybe have contributed to the high-echo and
hybrid-echo plaque formation. 3. Female may be a risk gender lead