内分泌代谢疾病与男性不育症.pdf

该【内分泌代谢疾病与男性不育症 】是由【小泥巴】上传分享，文档一共【5】页，该文档可以免费在线阅读，需要了解更多关于【内分泌代谢疾病与男性不育症 】的内容，可以使用淘豆网的站内搜索功能，选择自己适合的文档，以下文字是截取该文章内的部分文字，如需要获得完整电子版，请下载此文档到您的设备，方便您编辑和打印。:..??????2023?1??32??1?·133·DOI:.1004-·??·?????????????*???,??,??(???,?????????????430060)【??】??????????????х???????????,???????б??50%。???????,??,??????????,??????????????。???????э??????????????????,?????)3PRTC(3??????????/q1C??????、???????э?????????。????????????,????????,????????,??????????????,??,??????э???????,???????????????(VEGF)?????????。????????,???????(???????)?????+2aC???cAMP??、?????????????、????????????????。【???】???;??;???;?????【?????】R58;【?????】A??????????????????????????????????????????????????-??,?????,???????*????????????????????????????,???????????????????????????????,?????430060【????????】Infertilityreferstofailuretopregnancywithoutcontraceptivemeasuresformorethanoneyearinaregularsexlife,ountforabout50%.Amongmaleinfertility,,,andchangingthesecretionofadipokinessuchasleptin,plementC1q/tumornecrosisfactorassociatedprotein3(CTRP3).Abnormalglucosemetabolism,,,abnormalthyroidfunctionincludinghyperthyroidismandhypothyroidismalsoaffectsemenqualitybyaffectingtestosteronesecretion,regulatingcyclin-dependentkinaseinhibitor,upregulating2+cAMPsynthesisandCarelease.【????????】Infertility;Obesity;Diabetes;Thyroiddisease(??????????2023,32(01):133-137)??????????????х??????????????????????,????,???,???????э??????????????????,]1[?????、?????15%,???????б??50%[2]。????????????????,????、????,?【????】2022-07-04;【????】2022-08-03????????、???,??????????【????】????????(81971356)?????,????????????????【????】???,?,?К???,?????,????[3]??.(*????)???????。???????????,?:..·134·??????2023?1??32??1???????????????????。?Ч?????????????)CRP(????[8],???,???????????????。?????????????????????????????????,????????????????????,????、???、???,???[9]?,????????????,???????。?х????。????????、?,??????6-IL、)Bκ-NF(Bκ????????????????,????????????????????,?????%30??????12%[4]。?。??????????,????????、????,???????????????、2????、??????、δ??,????????,?????????????????????????????Ф????。??(unfoldedproteinresponse,UPR)????????[5]???????4366????????,????[10]。?????????,?????????????(BMI)????????????,????????????,?????3-???????BMI??,?????、???????,??(3-Methyladenine,3-MA)????????[11]??????????。?????????????????????。????????。????????????(leptin)??????????????????????,C1q/??????????(C1q/TNF-related??????????????θ?,?????proteins,CTRPs)????э?????????????????????????。?????э????。????????、?????、????????????????????????б,???,????????????????,??。??????????????。?????????、?????????????????????????,??????????,?????????。????????。??????????3??????????????????э。(suppressorsofcytokinesignaling3,SOCS3)?????????131??????160??????????????????,??????????,б????????????,????????,SOCS3???????????[12]。SOCS??????(T)??????(LH)??????????JAK-STAT?????,D’Cruz?,???]13[?????????,??????)2E(???JAK/STAT???????????[6]???,????????????SOCS3????????。????????????????????э?????STAT/JAK??????。???????????????????????E2(PGE2)????,PGE2???????。???(Prostaglandintransporter,PGT)???????????????????????????????(prostaglandinEreceptor,EP)?,?TNF-α???????。???????,??,??cAMP/PKA/CREB(cAMP-response????????????????,?????elementbindingprotein,cAMP????????、???、??????????[14]。?????)??,??щ???????CYP19??[7],??????????AMPK????,????????????????。????????????1(specificityprotein-1,SP1)????????????,????????????????1-7TG???????,???????,?????????????-??-???,????????(GnRH)????KISS1???,????[15]????????。GnRH??。??????????????、?????????????????????????????,??????,??????,??,???????????????????????[16]。???????????????CTRPs????。???????,?????????,??????????α(TNF-α)、???6(IL-6)、C?????????。???????????,:..??????2023?1??32??1?·135·CTRP3????????Sirtuin1????????????????????????,??????,????????????????????????????????????э,[17]???θ。????????,????????????????????????。????Ф?????、?э?????????????????????????DNA??,?????Ф????,???????。?????????32??????????????、??、???,???????165?????,???????????、?????,???????Ф??。??,????????、???????θ?????????????,???????????????????[18]。?????????????40?????,????DNA?????3L(DNMT3L)??????,?????????б???????????[32]。????DNMT3L????????,?????L3TMND??????,]33[??????????????????,??。]19[?????。??????,?DNMT3L???????????????????????????????????????????,??????,?,???????????(GLUT)????????????[34]。????,?щ?RNA,????,??????????,?????????microRNA、siRNA?,?????э???????(MCT)????????????????????????[32]。?????????[20]。??,????????????????(VEGF)????????????????[21],?????????????,VEGF?э????????э??????[22]。??,??????????GLUT1???。2018????????,????????GLUT4????,?????????????,PI3K/AKT??Ф??,?????VEGF???[23-24]??????。??,???????????,????????[35]????????????????,?????????????。?????????????????????????、??????????э?????????????????,??????????????-??-???。??(HPG)?????????????????、???????????[25]。??????????????????????????????????????,????????,??????????????????????????[26],???(ROS)??????????????????[36]。????????????????????4T?3T?????????ROS???????。??。???????,ROS????????μ???T3??????,??????????,??????????????????????????????????。???T3???LH????[27],??????????????????????ROS????,?T3????????????[28],ROS??????,??????;??????????????????T3????DNA??????[29]。???????????????????????27Kip1?p????,1piC21?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