中医药治疗慢性乙型肝炎免疫机制探索.ppt

该【中医药治疗慢性乙型肝炎免疫机制探索 】是由【落意心冢】上传分享，文档一共【45】页，该文档可以免费在线阅读，需要了解更多关于【中医药治疗慢性乙型肝炎免疫机制探索 】的内容，可以使用淘豆网的站内搜索功能，选择自己适合的文档，以下文字是截取该文章内的部分文字，如需要获得完整电子版，请下载此文档到您的设备，方便您编辑和打印。中医药治疗慢性乙型肝炎免疫机制探索汇报提纲HBV感染免疫研究进展(researchprogress)不同感染状态免疫应答特点(thecharacteristicofimmuneresponseindifferentinfectionstates)中医药治疗慢性乙型肝炎免疫机制(theimmunoregulatorymechanismofCHBwithTCMtherapy)免疫学:内外平衡中医学:阴阳平衡1、:307–36JournalofGeneralVirology(2019),87,1439–1449Acute,Self-LimitingHBVinfectionVigorous,heterogeneousCD4+THresponsetoHBe-HBcantigensWeakerresponsetoviralenvelopeproteinsVigorousCTLresponsetoenvelope,polymerase,HBcAgandHBeAgTH1responseisdominant:APC++LysisofInfectedHepatocytesVirusNeutralizationInhibitorsTH1CTLTH2BIL-10IL-4TNFαIFN-γInhibitionofHBVChronicHBVInfectionPredominantbutweakCD4+responsetoHBe-HBcantigensRelativelyweakandnarrowlyfocusedweakCTLresponse;chronichepatocytedestructionMaintenanceofcarrierstatecausedbyanimbalanceintheHBeAg/HBcAgspecificTHcytokineresponses(Milich,2019)TH2responseisdominant:Seroclearance(HBeAg/HBsAg)associatedwithmajorimmunologicalchangesinTH1/TH2balance+APC+AntibodyInhibitorsTH1CTLTH2BIL-10IL-4NoLysisofInfectedHepatocytesTTh1Th2Th?Tc1Tc2Th0CD4+TcCD8+CD4+T细胞与CD8+T细胞responseofhelpTcellscytokineproduction,participatinginCTLresponseandhumoralimmunityresponseofCTL:clearanceoftheinfectioncellsresponseofregulatoryTcells:regulatingtheresponsetovirusinfectionCTLHBV+Fas-LPerforinHBV-DirectcytolysisNon-ytokine-mediatedHBVcontrolChemokines(,10)RecruitmentofPMNsMatrixMetalloproteinasesRecruitmentofNK,T,M?cytokinesCD8TcellinducedliverdiseaseandviralclearanceinHBVinfectionDiseaseamplificationHBV-HBV-;5(3):215-