现代医药卫生年月日第卷第期
·1486· 2012 5 30 28 10 J Mod Med Health,May 30,2012,,
·论著·
高效液相色谱法测定厄贝沙坦胶囊中厄贝沙坦的含量
蒋梁(长沙市第一医院药剂科,湖南长沙 410004)
摘要目的建立厄贝沙坦胶囊中厄贝沙坦的含量测定方法方法色谱柱柱流动相乙***
【】。:Dianmonsil C18 ; : -
%磷酸二氢钾溶液(用磷酸调至 )45∶55;检测波长:245 nm;流速: ml·min-1。结果厄贝沙坦线性范围为
~ μg·ml-1,相关系数 r= 9,回收率为 %,相对标准偏差(RSD)为 %。结论所建立的高效液相色
谱法简便、可靠、重现性较好,能起到控制厄贝沙坦胶囊中厄贝沙坦含量的作用。
【关键词】胶囊; 厄贝沙坦; 色谱法,高压液相
文章编号: 1009-5519(2012)10-1486-02 中图法分类号: 文献标识码: A
Determination of irbesartan content in Irbesartan Capsule by HPLC JIANG Liang(Department of Pharmacy,Chang-
sha Municipal Hospital,Changsha,Hunan 410004,China)
【Abstrct】 Objective To establish a HPLC method for the determination of irbesartan content in Irbesartan Capsules.
Methods The irbesartan content was determined by the HPLC method,using the Dianmonsil C18 column,acetonitrile- mol·l-1
potassium dihydrogen phosphate solution (adjusted to pH with phosphoric acid)(45:55) as the mobile phase. The detection
wavelength was 245 nm. The flow rate was ml·min-1. Results The linear range of irbesartan was - μg·ml-1,the
correlation coefficient r was 9. The average recovery was % with RSD %. Conclusion The method is simple,
rapid and accurate with good repeatability,which can be used for controlling the content of irbesartan in Irbesartan Capsules .
【K
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