A nm23的表达及临床意义.doc

A nm23的表达及临床意义
作者:李素清马小彬郑辉宇
【摘要】目的:研究增殖细胞核抗原(proliferating cell nuclear antigen,PCNA)和肿瘤转移抑制基因nm23在脑胶质瘤中的表达与肿瘤病理分级的关系,探讨在胶质瘤预后判断上的价值。方法:A和nm23的表达。结果:PCNA在胶质瘤中绝大部分阳性表达,在正常脑组织中全部阴性表达,PCNA在胶质瘤的表达明显升高(P ),并随恶性程度增高而升高(P );nm23基因在正常脑组织中全部阳性表达,胶质瘤中部分阳性表达,nm23在胶质瘤的表达明显降低(P ),且随恶性程度增高而降低(P )。两者呈负相关。结论:PCNA、 nm23检测可能成为脑胶质瘤诊断及判断恶性程度与预后的指标。
【关键词】脑胶质瘤增殖细胞核抗原 nm23基因免疫组织化学表达
The Expression and Significance of PCNA and nm23 in Brain Glioma
Abstract:Objective:To investigate the expression of the proliferating cell nuclear antigen(PCNA) and metastasis suppression gene nm23 and their relation to pathology in brain glioma,to discuss the value in brain glioma prognosis estimation. Method: Immunohistochemical staining method was used to study the expression of PCNA and nm23 in 47 cases of brain gliomas and 12 cases of normal brain tissues. Result:PCNA almost positively expressed in gliomas and all negatively expressed in normal brain tissues,the expression in gliomas was more higher than in control group (P )and increased along with the growing of pathology grade(P );nm23 gene all positively expressed in normal brain tissues ,partly positively expressed in brain gliomas ,the expression in gliomas distinctly decreased(P )and decreased along with the growing of pathology grade(P ). Conclusion:This study indicate that the expression of PCNA and nm23 may be a usef