INTERACTIVE A MODEL TO ACCOUNT FOR TRAINING-INDUCED NEUROPLASTICITY IN OLDER ADULTS AND PERSONS WITH MILD COGNITIVE IMPAIRMENT.pdf.pdf

P158 Featured Research Sessions: F2-02: In Vivo Insights On The Regional Specificity of Alzheimer’s Disease Pathology
examined whether 1) MCI patients could independently use MST, 2) MST F2-01-04 INTERACTIVE: A MODEL TO ACCOUNT FOR
was more effective than spaced retrieval training (SRT), 3) prefrontally- TRAINING-INDUCED NEUROPLASTICITY IN
based cognitive control regions were critical for MST ess. Methods: OLDER ADULTS AND PERSONS WITH MILD
Sixty patients with MCI were randomly assigned to MST or SRT. COGNITIVE IMPAIRMENT
pleted five sessions within 2 weeks. During sessions 1
Sylvie Belleville1, Benjamin Boller2, Benjamin Zendell3, Samira Mellah4,
and 5, participants underwent fMRI scanning during both the encoding 1
Research center, Institut Universitaire de Geriatrie de Montreal, Montreal,
and retrieval of object location associations. During sessions 2-4, MST par- 2
Quebec, Canada; Research Center, Institut Universitaire de Geriatrie de
ticipants were taught a 3-step process where they attended to a salient envi- 3
Montreal, Montreal, Quebec, Canada; International Laboratory for Brain,
ronmental feature, developed a verbally-based reason linking the feature
Music, and Sound Research and Research Center, Instituteitut Universitaire
and object, and then created a mental image. The SRT group was matched 4
de Geriatrie de Montreal, Montreal, Quebec, Can