Abstract Objective: To investigate the Evaluation of contrast enhanced bined with ultrasound elastography in diagnosis of thyroid nodules,and search the best imaging method for the early differential diagnosis of thyroid nodules . Methods: 50 patients with thyroid nodules were chosen from November 2013 to December 2014 at Affiliated Hospital of Qinghai University whom undergoing thyroid operation. Record all the patients’general condition and symptoms,signsand other clinical data in detail. First, examined patients by conventional and color Doppler ultrasound to get the best sections of the lesionsand and record the location、 size、number 、internal echo and the interior blood-flow circumstances of the masses, to make an early diagnosis .Then switched to the ultrasound elastography mode. Frozen storage figure when obtain more accurate elastic image, to observe the nodules shown in the color difference in elastic image and made elastic classification. Then switched to the contrast mode. Injected by cubital vein,then 5ml of saline the dynamic contrast-enhanced ultrasound progress and record 3mins. Downloaded all the pictures and progresses to be analyzed. Observed the contrast enhancement patterns of thyroid nodule .Selected the parts for lesions and normal tissue around as ROI area, got the time-intensity curves (TIC) and imaging parameters imaging figure through the software analysis ,to observe the amount of contrast agent in and out of the lesions, the speed and form. Made an ultrasonic imaging diagnosis. Patients were followed up the CEUS results pared with the postoperative pathological findings . and statistically analyzed all the results . Results: 1. 28 cases of 50 patients with thyroid nodules were benign. The elasticity imaging score were most in the three points and the following, and the elasticity imaging figure is given priority to with yellow-green .The CEUS characteristics mainly performance ring enhancement