二陈汤3种剂型的药理作用对比研究论文.doc

二陈汤3种剂型的药理作用对比研究论文.doc二陈汤3种剂型的药理作用对比研究论文
陈玉兴黄雪君曾晓会赵自明
【摘要】目的对比研究二陈汤新工艺制剂、标准煎剂和丸剂止咳、平喘、祛痰作用。方法采用小鼠氨水引咳、豚鼠磷酸组***诱喘、小鼠气管酚红排泄方法进行3种剂型药理作用对比实验。结果二陈汤新工艺制剂、标准煎剂和丸剂均可明显延长氨水引咳小鼠的咳嗽潜伏期、延长豚鼠磷酸组***吸入翻倒发生时间、增加小鼠气管酚红排泄量,3种制剂等剂量组比较,功效上二陈汤新工艺制剂优于标准煎剂与丸剂。结论二陈汤新工艺制剂、标准煎剂和丸剂均有明显止咳、平喘、祛痰作用,功效上二陈汤新工艺制剂较佳。
【关键词】二陈汤止咳平喘祛痰
Abstract:ObjectiveTo pare the differents of Erchen soup preparation on anti-tussive, expectoran,anti-asthmatic actions. MethodsThe anti-tussive,anti-asthmatic and expectorant effects monia method , spray method in cavies and increased the secretion of expectoration method in mice. ResultsErchen soup preparation had inhibitory effect on cough caused by concentrated ammonia in mice,prolonged the latency of cough,decreased the frequency of cough,and increased the secretion of confection also had significant inhibitory effects on asthma in soup preparation has excellent anti-oxidative, expectoran, anti-asthmatic effects. And Erchen soup preparation atic
“二陈汤、逍遥散及广佛手等7味配方颗粒质量标准的示范性研究”是根据国家“十五”期间建设中药现代化科技发展规划而设置的课题,其在中药配方颗粒前期研究工作的基础上,开展了新工艺、新技术、新方法、新辅料在中药配方颗粒中的应用研究,以期建立单味中药配方颗粒及复方颗粒示范性制备工艺及示范性质量标准。二陈汤,初见于宋代《太平惠民和剂局方》.freelin,记录小鼠咳嗽潜伏期和1 min内的咳嗽次数。
二陈汤新工艺制剂、标准煎剂和丸剂对豚鼠整体磷酸组***吸入诱喘的影响[2]取豚鼠80只,雌雄均用,随机分为对照组、二陈汤新工艺制剂组、二陈汤标准煎剂组、二陈汤丸剂组。二陈汤3个剂型组各分为高、中、低各3个剂量(,, g生药/kg)组。各给药组按剂量灌胃给药,对照组给予等体积蒸馏水,1次/d,连续7 d。末次给药后1 h,逐只将豚鼠放入YLS-8A多功能诱咳引喘仪中,%磷酸组***气雾,记录开始喷雾至豚鼠翻倒发