Highly Efficient One-Pot ponent Mannich Reaction in Water Catalyzed by Heteropoly Acids
Najmodin Azizi, Lalleh Torkiyan, and Mohammad R. Saidi
Department of Chemistry, Sharif University of Technology, . Box 11465-9516, Tehran 11365, Iran
Org. Lett., 2006, 8 (10), pp 2079–2082
DOI:
Publication Date (Web): April 20, 2006
Copyright © 2006 American Chemical Society
Abstract
Heteropoly acids efficiently catalyzed the one-pot, ponent Mannich reaction of ketones with aromatic aldehydes and different amines in water at ambient temperature and afforded the corresponding β-amino pounds in good to excellent yields and with moderate diastereoselectivity. This method provides a novel and improved modification of the ponent Mannich reaction in terms of mild reaction conditions and clean reaction profiles, using very a small quantity of catalyst and a simple workup procedure.
Carrying anic reactions in water has e highly desirable in recent years to meet environmental use of water as a sole medium anic reactions would greatly contribute to the development of environmentally friendly processes. Indeed, industry prefers to use water as a solvent rather than anic solvents. In this context, in recent years, much attention has been focused on Lewis acid anic reactions in water.
Heteropoly acids (HPAs) are environmentally benign and economically
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