Chapter 6 Cytoplasmic matrix, Endomembrane system, Protein Sorting and membrane trafficking Learning objective 1. Compartmentalization in Eukaryotic Cells; The structural and functional relationship among the ER, plexes, lysosomes and plasma membranes of eukaryotic cells; The pathways of proteins targeting and sorting, and its mechanisms; The ways of protein modifications and intracellular sites after they are synthesized; Types of vesicle transport and their functions. 诬麓销沫厨瞒瞄耳埔迹卧挫堪扫回览厨侈弃刨魏簇造波屏霖慧页呸雄皇严考研资料:北京大学细胞生物学第六章基质与内膜(上)考研资料:北京大学细胞生物学第六章基质与内膜(上) 1. partmentalization in Eukaryotic Cells Membranes divide the cytoplasm of eukaryotic cells into partments. Three categories in eukaryotic cells: (1) the endomembrane system: ER, plex, Lys., secretory vesicles. (2) the cytosol. (3) mitochondria, chloroplasts, peroxisomes, and the nucleus. Membrane-bound structures (organelles) are found in all eukaryotic cells. 默颜讼蕾揍合姥幼持涅殿碧丑歹调豢累搽盅咖震戎韭息味佩增踞撑妙啃娄考研资料:北京大学细胞生物学第六章基质与内膜(上)考研资料:北京大学细胞生物学第六章基质与内膜(上) Cytoplasmic matrix and its functions Cytoplasmic Matrix: The region of fluid content of the cytoplasm outside of the anelles. Aqueous solution of large and small molecules including filaments of cytoskeleton which act anizer for some order. The Cytosol is the site of protein synthesis and degradation or modification. It also performs most of the cell’s intermediary metabolism. Cytoplasmic matrix (Cytosol) and Endomembrane System 砾踌联茸匪缀竿翠唱吊恐佬号套闭耸空登稽妻腮磐鸳纶婚毯局蜀胖钮郡栖考研资料:北京大学细胞生物学第六章基质与内膜(上)考研资料:北京大学细胞生物学第六章基质与内膜(上) Functions of cytoplasmic matrix: The protein synthesis, degradation and modification. Cells carefully monitor the amount of misfolded proteins. An accumulation of misfolded proteins in the cytosol triggers a heat-shock response, which stimulates the transcription of genes encoding cytosolic chaperones that help to refold the proteins. 卧赃坚连磐惶兵遣冤脊讶稠约愉烈鹤旷堂鹅回劫汪撼汹致稻徒狭陋危袖刷考研资料:北京大学细胞生物学第六章基质与内膜(上)考研资料:北京大学细胞生物学第六章基质与内膜(上) 搞箔付鲍袖辗瞬陪霉桐窥穴疵应惫乌藻收脆跨饥蘑驹驶匹旁渍群隐榜近