Respiratory Failure 呼吸衰竭 Respiratory Failure Respiratory Failure is a syndrome in which the respiratory system fails in one or both of its gas exchange function: oxygenation氧& carbon dioxide 二氧化碳 elimination. PaO2 60 mmHg or PaCO2 50 mmHg Acute respiratory failure is present when alveolar ventilation is inadequately to meet the body’s need; the lung can no longer adequately oxygenate the blood. Respiratory Failure Risk factor: The critically ill patient The patient who has undergone recent abdominal 腹部or thoracic胸部surgery, as a result of splinting夹板of the incision切口, abdominal distention, restrictive bandages绷带, tubes引流管, and reduced ventilation通气减少because of pain. The extremely obese肥胖patient because of restriction of ventilation. The patient who has sustained a thoracic or spinal cord脊髓injury atose昏迷patient or patient with decreased level of consciousness and depression of the respiratory center. The patient who has lung disease or who smokes, especially when an infection develops or surgery is needed. The immunosuppressed免疫抑制patients The older adults Chronic respiratory failure - days or longer - pH is slightly decreased; allowing time for renal compensation and an increase in bicarbonate concentration Classification Acute respiratory failure - minutes or hours - pH Type I: Hypoxemia Respiratory Failure低氧血症呼吸衰竭
PaO2 60 mmHg with a normal or low PaCO2 mon: Associated to all acute diseases of the lung Involve fluid filling or collapse塌陷of alveoli (cardiogenic or noncardiogenic pulmonary edema, pneumonia, hemorrhage出血) Classification Type II: Hypercapnia Respiratory Failure高碳酸血症呼吸衰竭 PaCO2 50 mmHg with hypoxemia (severe airway disorders . asthma, COPD, drug overdose吸毒过量, neuromuscular disease神经肌肉疾病, chest wall abnormalities胸壁畸形) Classification Mechanisms of type I respiratory failure Mechanisms that may cause hypoxemia and subsequent hypoxemic respiratory failure are: Ventilation-Perfusion (V/Q) mismatch通气血流比例失调 Sh