Abstract Elizabeth Gaskell(1810-1865)is an important realistic novelist in England during the mid-eenth century. Her works cover a wide range of subjects and profound thoughts, which attract the great attention from domestic and overseas critics, especially the issues like the contradiction of the capital and the labor, humanitarian care and ethical problem in her works. However, less attention has been paid to the problem of alienation of human nature. The famous American psychologist Erich Fromm puts forward the theory of “alienation of human nature”. He thinks that alienation is the experiential process of human‟s spirit and mentality. It means that human‟s certain physiology and psychology start to change under the political and economic factors of capitalist society, then which lead to the alienation of human nature. While Fromm hopes that the alienation of human nature could be eliminated by love and tolerance, thus establishing a humanitarian public ownership society. Fromm‟s “alienation of human nature” provides theoretical basis and prospective to study the alienation and redemption of human nature which embody in Gaskell‟s novels Mary Barton and Ruth. With Fromm‟s theory of alienation of human nature, the thesis pays attention to the analysis of the seamstresses Mary Barton and Ruth‟s alienation and redemption of human nature in Mrs. Gaskell‟s novels Mary Barton and Ruth. It explores Mrs. Gaskell‟s reflection and critique towards the exploitation of capitalist system and traditional moral concept, and further reveals Gaskell‟s view of humanism which base on love and tolerance. Chapter one introduces alienation of seamstress‟s human nature. Facing the oppression and bondage of the traditional patriarchal social system in eenth century and the feeling of loneliness and helplessness in the process of women‟s individualization, Mary and Ruth take the alienated ways of pursuing fanciful love and accepting hopeless thought of being a sinful origin in people‟