ct引导下经皮微波消融作为进展期非小细胞肺癌的维持治疗新手段-肿瘤学专业毕业论文.docx

山东大学博士学位论文
CONTENTS
Abstract in Chinese ·1
Abstract in English-·_-···· ·····-·-·······················-········································································-······················‘···-····_-··’4 Abbreviating Words‘·····-·····-_·-······················-··························-·············_············································-··················-····--·-‘8 Text
l Introduction 一1 0
2 Materials and Methods
Inclusion and Exclusion Criteria- ·12
Course of treatment
First—line treatment 1 3
MWA procedure 14
Follow-up and treatment assessment ’1 8
Statistical Analysis ‘2 1
3 Results
’22
Local efficacy ’23
Survival “23
4 Discussions 25
5 Conclusions······························ ······ ·· · ·- 29
6 Appendix’···········································-················· · ··-·· ·· ·· ··_-· ·····················-··········。···‘· · ·· ’30
7 Reference ···· ··_···· ····················································· · · ·- 43
Acknowledgements‘········-··_····--········_-··-··-·········_··-·····-····_·-_····_······_······_···-·······_········-·-··-_··-···--··--······················_·······-·’50 Published Articles During the MD’····-····_··‘·-····· ·‘·····‘·····。·····-·-····_··^···-_··········-·····-···········-_···‘·。-··-····_·-····‘5 1 Dissertation appraisement-····················································································-············-··-·-··-··············‘·‘·············’52 Articles in English
Articles in English ”53
Articles in English ’········_············_·········-··_·_··············· · ·· · ···························································‘74
万方数据
山东大学博士学位论文
摘要目的:肺癌是世界范围内癌症的主要死因,中国是世界第一肺癌大国,肺癌居我国癌症发病率和死亡率的首位。非小细胞肺癌占全部肺癌病例的89%。进展期非小细胞肺癌失去了根治性手术的机会,目前以系统化疗为主要治疗手段。然而, 传统一线治疗已经达到了疗效平台,总缓解率25%.35%,, ,%,%。大多数患者在一线治疗期间就出现了进展,即使是经一线治疗达到缓解或稳定的患者,最终也不可避免地出现进展,因此,总体上患者预后极差。
对于经一线治疗达到缓解或稳定的患者,采用非铂