丙泊酚对小鼠小脑皮层分子层和颗粒细胞层感觉信息传递的影响-生理学专业毕业论文.docx

延边大学博士学位论文 List ofAbbreviations
CONTENTS
Abbreviations 3
Chapter 1.
Propofol modulates sensory information processing in cerebellar molecular layer in vivo in mice. 。4
Abstract 5
Introduction, 9
Experimental procedure ‘ 一 1l
Anesthesia and surgical procedures 一 ll
ElectrophysioIogical recordings and drug application ’n
Statistical analysis 11
1-3 Results 12
Effects of propofol on the facial stimulation—evoked field potential responses
in cerebellar molecular layer J12
Propofol affected sensory responses via the modulation of GABAA receptor
Discussion 一一一一20 Propofol inhibited the sensory‘stimulation evokes ponent of field potential responses in cerebeHar molecular layer 。~一 ~ 一。20
Propofol enhanced the sensory stimulation evokes ponent of
field potential responses in cerebeHar molecular layer。、 ~一 1~1—2l Propofoi modulated the sensory stimulation-evoked field potential responses in cerebeHar molecular layer via GABAA receptor ·一一22 Conclusion 一24
References .25
万方数据
延边大学博士学位论文 List ofAbbreviations
Chapter 2.
Propofol enhances facial stimulation-evoked responses in cerebeilar granule cell layer via activation of NMDA receptor/n vivo in mice 。 28
Abstract 29
Introduction 、。 ,、 35
Experimental procedure ~ 一_38 Anesthesia and surgical procedures 38
Electrophysiological recordings and drug appfication 38
Chemicals 。一剪
Statistical analysis 一,‘一一- 钞
23 Results 一.. 一舶 Effects of propofol on the facial stimulation—evoked矗eH potential responses in cerebeilar granule cell layer 40
Blocking GABAA receptor activity failed to prevent the propofoi enhanced facial stimulation-evoked R佣in cerebellar granule cell layer 一,·,一 43
233 Blockade of NM圃IA receptors activity attenuated facial stimulation-evoked R蚰,and abolished the propofol-induced enhancement of R孵一~ |45 Discussion, . ., 。一. .。一、.。..,.~ 。,.。..,...。。48
P roperties of sensory in