Abstract The glacier is a solid reservoir and a profound impact on climate changes. It can also affect the local micro-climate and ecological environment. Mountain glaciers are the headstream of many large rivers. Especially, as water resources, it is very important to maintain production and living in arid areas. Glaciers are sensitive indicator of climate change. Under the global warming, it is true that glaciers in Western China with varying degrees of retreat. The study of glacier changes over the past 50 years in Heihe River Basin not only can master information of size and distribution characteristics, but also understand the rate of glacier change and the response to climate. And then it would provide this basin for an evaluative basis of using and protecting glacial freshwater resources. Multi-temporal satellite remote sensed data and images are analyzed by using GIS and RS technology in this study. The thesis mainly studies information and variation of quantity, area, length, terminal elevation and terminal aspect over the past 50 years in Heihe River Basin, besides, analysises temporal and apatial characteristics of temperature and precipitation and their trends from 1957 to 2010 in the region. Finally discusses response of glacier change to climate change. From 1957 to 2010, the mountains of the Heihe River Basin has been warming at a rate from to ℃ percent ten years. It is much higher than the global average warming rate which is degrees per ten years, and therefore the climate of the mountains is in a rapid warming trend. This is the primary reason for rapid glacier retreat and disappearance. The precipitation increased at a rate from to mm percent year, but it can not prevent the trend of turning glaciers into smaller and less. In this region, the annual precipitation and the summer precipitation are markedly increased, but summer precipitation often takes the form of rainfall. It is not only bad for accumulation of glaciers,