第九届全国超临界流体技术学术及应用研讨会论文集
PGSS 技术制备布洛芬纳米颗粒
陈雯雯周园洪燕珍苏玉忠王宏涛李军
厦门大学化学化工学院化学工程与生物工程系,福建省厦门市, 361005
布洛芬是临床上常用的非甾体抗炎、镇痛、解热药,但其制剂存在水溶性差、生物利用率低等问题。本研
究应用改进的 PGSS 实验装置,制备布洛芬纳米粒子。初步考察了若干预膨胀压力、预膨胀温度等工艺参数对所
制备得到的颗粒粒径及形貌的影响。此外,对布洛芬颗粒的溶出度进行测定。
关键词:布洛芬,纳米粒子, 超临界流体, 气体饱和溶液
Preparation of Ibuprofen Nanoparticles by PGSS Technique
Wen-wen CHEN,Yuan ZHOU, Yan-Zhen HONG, Yu-Zhong SU, Hong-Tao WANG,
Jun LI
Department of Chemical Engineering and Biological Engineering, Xiamen University, Xiamen 361005, Fujian,
China
Ibuprofen is mon non-steroidal anti-inflammatory, analgesic and antipyretic drug used in clinical treatment.
But there are problems of low water-solubility and low biological utilization. In this study, improved PGSS was used to
prepare ibuprofen nanoparticles. The effects of pre-expansion pressure and pre-expansion temperature of the
gas-saturated solution on particle size and morphology were preliminarily study. In addition, the dissolution properties of
different ibuprofen particles were investigated.
Key words:ibuprofen, nanoparticles, supercritical fluid, gas-saturated solution
1 前言
目前市场上使用的特效药物多为非水溶性药物,它们由于低溶解性,在临床应用中面临着生
物利用率低、稳定性差等问题。目前越来越多的学者致力研究纳米颗粒制备,试图通过减小颗粒
尺寸以增加颗粒的比表面积,从根本上提高溶解度从而提高药物的生物利用度[1H ]。超临界流体H
技术作为一种条件温和、适应性广的技术受到越来越多的关注,目前对于运用超临界流体技术制
备药物纳米颗粒的报道大多是运用RESS技术,相对于PGSS技术,该技术存在超临界流体消耗量大
的缺点。但是目前很少有关于PGS
PGSS+技术制备布洛芬纳米颗粒 来自淘豆网www.taodocs.com转载请标明出处.