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inhibitors. For example, the G9a inhibitor UNC0638
reactivates silent retroviral inserts3. This may be useful in the context of cellular reprogramming strategies, but it raises safety issues about the use of histone
methyltransferase inhibitors in patients.
Much remains to be learned about histone
methyltransferases and their potential as therapeutics and diagnostics. We look forward with great interest to further developments, especially the first clinical studies of histone methyltransferase inhibitors, which may begin soon
How Cells Cope with Obesity
Freelance Science Writer, San Diego, California, United States of America Citation: Sedwick C (2011) How Cells Cope with Obesity. PLoS Biol 9(6): e1001077. doi:.1001077
Published: June 7, 2011
Copyright: ? 2011 Caitlin Sedwick. This is an open-access article distributed under the terms of the mons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Currently, more than million American adults are diagnosed as obese each year. Many of these people
suffer from a disorder known as metabolic syndrome, which includes symptoms like hypertension and elevated blood cholesterol. They are also at risk
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