展看危重症患者血清胆碱酯酶水平和APACHE II评分相关性.doc

展看危重症患者血清胆碱酯酶水平和APACHE II评分相关性.doc展看危重症患者血清胆碱酯酶水平和APACHE II评分相关性
王辰,朱宇清,曾庆,孙洪涛,支力大,吴健敏【目的探索危重症人群血清胆碱酯酶(ChE)水平和APACHE Ⅱ评分的关系。方法对116例收进EICU 24h内的危重患者的血清胆碱酯酶水平进行测定,并测定30例正凡人的血清胆碱酯酶水平对照分析,比较两组间的差异。同时对这116例患者进行APACHEⅡ评分,按照APACHEⅡ评分分值的高低分成3组(&lt;15分组、15~20分组、&gt;20分组),比较不同组别间血清胆碱酯酶水平的差异。将本组116例危重症患者按照是否死亡分为死亡组和存活组,比较两组间血清胆碱酯酶水平的差异。结果(1) 危重症患者的血清胆碱酯酶均匀水平较正凡人明显降低(P<)。(2)危重症患者的血清胆碱酯酶水平和其APACHEⅡ评分的分值成负相关(r=-,P<),病情越危重,APACHEII评分分值越高,死亡率越高,相应血清胆碱酯酶水平越低下(P<)。结论血清胆碱酯酶水平是反映危重症病情及评价预后的一项重要参考指标。

【危重症患者;血清胆碱酯酶;APACHE Ⅱ;评分


【Abstract Objective To study the relationships bet cholinesterase measurement of critical care patients and acute physiological and chronic health evaluationⅡ. Methods The levels of serum cholinesterase in 116 critical care patients and 30 normal people etric method to find their difference. A severity of illness score (APACHE
Ⅱ) ined for each patient during the first 24 h in the EICU,at the same time,serum cholinesterase easured. First,these patients cholinesterase levels in critical care patients arkedly loal people (P<).(2) The serum cholinesterase levels in critical care patients cholinesterase level might be an important index reflecting the critical care patient’s condition,and an index for estimation of the prognosis.

【Key cholinesterase; APACHE Ⅱ scores

血清胆碱酯酶是一类糖蛋白,主要存在于脑、肝、血及胆碱能神经末梢的突触间隙中。在目前临床中,测定血清胆碱酯酶活性是协助诊断有机磷中毒和评估肝实质细胞损害的重要手段。由美国学者Knaus发明的APACHE Ⅱ(