肠道感染病毒.ppt

Enteroviruses
Feng-Min Zhang
Microbiol Departman, Harbin Medical University
第31章肠道病毒
问题
肠道病毒有哪些?是不是肠道感染的所有病毒都称为肠道病毒?
简要说明肠道病毒的特性
脊髓灰质炎病毒的传播途径、致病机制是什么?如何预防脊灰?
B组柯萨奇病毒的致病有何特点?
ECHO病毒、轮状病毒、杯状病毒、小圆结构病毒分别与哪些疾病有关?
Groups and Serotypes
Picornaviridae(小RNA病毒科)
At least 71 serotypes, divided into 4 subgroups
Polioviruses (脊髓灰质炎病毒)
Coxsackie viruses(柯萨奇病毒)
Echoviruses(埃可病毒)
New enteroviruses(新肠道病毒)
more recently, new enteroviruses subtype have been allocated sequential numbers (68-71))
Enteroviruses Serotypes
Morphology
27nm, icosahedral symmetry, no envelope
Surface cleft – attachment to cellular receptors:
Immunoglobulin superfamily, integrins, ICAM-1
Enterovirus structure
肠道病毒的特点
小球形病毒(~ 30 nm),无包膜
核酸为+ssRNA,有感染性
衣壳有VP1—VP4四种蛋白,VP1—VP3分布在表面,VP4与内部RNA结合
耐酸耐***,但鼻病毒除外
在胞浆增殖,有明显CPE,破胞释放
引起多种疾病:麻痹性疾病、无菌性脑膜炎、心肌损伤、腹泻、皮疹等
Poliovirus-脊髓灰质炎病毒
Poliovirus was first identified in 1909 by inoculation of specimens into monkeys. The virus was first grown in cell culture in 1949 which became the basis for ines