人血清附睾蛋白4检测在卵巢癌诊断中的价值分析.docx

人血清附睾蛋白4检测在卵巢癌诊断中的价值分析
[摘要]目的通�^对卵巢癌、卵巢良性肿瘤、健康人群人附睾蛋白4、CA125检测,探讨HE4在卵巢癌诊断中的应用价值。方法选取赣州市肿瘤医院XX年5月~XX年12月符合入选标准的病例,采用电化学发光检测法对57例卵巢癌患者、49例卵巢良性肿瘤患者及100例体检健康者的血清HE4水平进行检测,并与CA125的检测数值结果进行比较分析。结果卵巢癌组的血清HE4水平为pmol/L,显著高于卵巢良性肿瘤组的pmol/L和对照组的pmol/L,差异均有统计学意义。HE4诊断卵巢癌的敏感度和特异度较高,不同方法联合HE4及CA125检测卵巢癌的敏感度和特异度可分别达到%和%,较单一肿瘤标志物的检测更具优势。结论血清中HE4水平对卵巢癌具有较高的诊断价值,是诊断卵巢癌新的血清肿瘤标志物之一。
[关键词]人附睾蛋白4;卵巢癌;肿瘤标志物;诊断
[中图分类号] [文献标识码] A [文章编号] 1674-47211-0126-03
Value analysis of serum human epididymis protein 4 in the diagnosis of ovarian cancer
LIU Lian-bin1 ZHOU Mao-hua1 YU Ying2 XUE Ling1 LI Rong3 WANG Qi2 ZHOU Xiao-juan1 LIN Wei1
of Clinical Laboratory,Tumor Hospital of Ganzhou City in Jiangxi Province,Ganzhou 341000,China; of Gynecology,Tumor Hospital of Ganzhou City in Jiangxi Province,Ganzhou 341000,China; of Pathology,Tumor Hospital of Ganzhou City in Jiangxi Province,Ganzhou 341000,China
[Abstract]Objective To explore the application value of HE4 in the diagnosis of ovarian cancer by detecting human epididymal protein 4 and CA125 in ovarian cancer,benign ovarian tumor and healthy From May XX to December XX,the cases that conform to the criteria for admission in Tumor Hospital of Ganzhou City were serum level of HE4 of 57 cases of patients with ovarian cancer ,49 cases of ovarian benign tumor patients and 100 healthy people were detected by electrochemiluminescence detection method,and