失巢凋亡与中医药抗肿瘤研究进展.doc

失巢凋亡与中医药抗肿瘤研究进展*通讯作者简介:沈克平,男,主任医师,硕士生导师,主要从事消化道肿瘤研究。地址:上海市宛平南路725号,龙华医院肿瘤五科邮编200032 电话:021-58835753-153 E-mail:shen0313@
沈克平,刘威,胡兵
(上海中医药大学附属龙华医院肿瘤五科, 200032)
摘要:失巢凋亡是细胞脱离胞外基质或与胞外基质不结合而发生的一种凋亡。失巢凋亡耐受是转移细胞的基本特性,可使肿瘤细胞在脱离与基质粘附状态时仍能存活。细胞失巢凋亡主要有死亡受体途径及线粒体途径。参与失巢凋亡的信号转导通路主要有磷脂酰肌醇3激酶AKT(PI3-k/AKT)通路和丝裂原活化蛋白激酶(MPAK)通路。近期发现癌基因 TrkB、抑癌基因PTEN也参与失巢凋亡调控。目前研究发现部分中药抗肿瘤的作用机制之一是抑制肿瘤细胞锚着不依赖性增殖,促进肿瘤细胞失巢凋亡。
关键词: 失巢凋亡;肿瘤转移;信号转导;中医药
基金资助:国家自然科学基金(30873258),上海市浦东新区中医领军型人才项目(PWZ2008-20-104)
Anoikis and anti-cancer effects of Chinese herbs
Shen-keping, Liu-wei, Hu-bing
5th Department of Oncology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine,
Abstract: Anoikis is a form of apoptosis induced by detachment of adherent cells from the extracellular matrix or inappropriate cell-matrix interactions. Resistance to anoikis is a hallmark of metastatic cancer cells which leads to cancer cells evading anoikis and thereby survive after detachment from their primary site, and metastasizing to ans. Both death receptor-mediated extrinsic pathway and mitochondrial-mediated intrinsic pathway contribute to anoikis. Phosphatidylinositol 3-kinase (PI3K)/Akt signal pathway and mitogen-activated protein kinase (MAPK) signal are major regulator of anoikis. In addition, oncogene TrkB and tumor suppressor gene PTEN may also contribute to anoikis regulation. Some studies suggested some anti-can