拉坦噻吗滴眼液治疗原发性开角型青光眼临床疗效观察.doc

拉坦噻吗滴眼液治疗原发性开角型青光眼临床疗效观
杨军韩芳(云南省第一人民医院眼科云南昆明650032)
【中图分类号】【文献标识码】A【文章编号】1672-5085 ( 2012) 27-0204-02 【摘要】目的评估对拉坦前列素滴眼液不敏感的原发性开角型青光眼患者,改用拉坦噻呵滴眼液治疗的疗效及安全性。方法己经用拉坦前列素滴眼液4周以上,且眼压未控制或未达到靶眼压的原发性开角型青光眼患者31例(60眼),改用拉坦噻吗滴眼液治疗,每t) 一次。结果换用拉圯噻吗滴眼液8周后,24小时眼压与基线眼压相比明显下降,差异有显著性(P<)。结论拉坦噻吗滴眼液与拉坦前列素滴眼液相比,对开角型青光眼眼压控制效果更佳。
【关键词】拉坦噻吗滴眼液拉坦前列素青光眼/开角型眼压
Efficacy of changing to the travoprost/timolol from prior latanoprost
therapy on patients with primary open-angle a
Yang Jun HanFang*
(Master’s degree,the First People7 s Hospital of Yunnan
Province, Kunming, 650032)
[Abstract] Objective To assess the safety and efficacy of changing to the travoprost/timolol from travoprost for patients with primary open-angle a whose intraocular pressure (I0P) was uncontrolled on latanoprost therapy or was not
on target. Methods Thirty-one POAG patients, whose target I0P could not be
satisfactorily acquired by latanoprost, turned to administrate evening-dosed latanoprost-timolol, 24-hour I0P curve before and 8 weeks after latanoprost/timolol
administration were recorded and its clinical IOP control effects were evaluated.
Results Before latanoprost/timolol administration, the mean 24-hour IOP was &plusmn; mmHg. After 8-week use of latanoprost-timolol, the mean 24-hour
IOP would be controlled at &plusmn; mmHg. There was statistical significance in 24-hour IOP changes between bef