放射性核素在骨骼系统疾病的诊断和治疗中临床应用进展.doc

放射性核素在骨骼系统疾病的诊断和治疗中临床应用进展.doc放射性核素在骨骼系统疾病的诊断和治疗中临床应用进展
(浙江省肿瘤医院核医学科浙江杭州310022)
【摘要】骨疾病的早期诊断和治疗非常重要,骨显像剂99mTc亚***二膦
酸盐(MDP)作为经典的骨显像药物在诊断骨转移瘤或其他骨疾病中发挥着重要的作用,但是还是不能满足临床对骨疾病的诊治的需求,因此需要大量的新型显像剂来弥补99mTc亚***二膦酸盐(MDP)存在的不足。如,99mTc乙二***四甲撑膦酸(HEDTMP)、153Sm—HEDTMP、177Lu 乙二***四甲撑膦酸(EDTMP)、99mTc-亚***氨基二膦酸(AMDP)18 F-***化钠(NaF)、11C-胆碱、11C-蛋氨酸(MET)等新型显像, 从亲骨性、血液清除率、对比度等各个方面得到提升,克服传统骨显像剂存在的不足。
【关键词】骨疾病;骨显像剂;膦酸盐;单光子显像;PET显像剂【中图分类号】R445 【文献标识码】A
【文章编号】2095-1752 (2016) 33-0007-02
The development of radionuclide bone imaging on bone diseases diagnosis and
clinical therapy Ni Faqiang, Nuclear Medicing Department of ZhejiangCancer
Hospital, Zhejiang Province, Hangzhou310022, China
【Abstract】 lt’s very important for early diagnosis of skeletal system
diseases, especially for bone tumor - MDP is a bone imaging agents
used for bone diseases monly; however, 99mTc -AMDP could not
satisfied for diagnosis and provied enough information for treatment.
Therefore,new bone imaging agents are need exploitation other
bone imaging agents have been development. For example,99mTc-HEDTMP,
153Sm—HEDTMP, 177Lu-EDTMP, 99mTc-AMDP, 18 F- NaF, 11C- MET,which appeared more seeker,better blood clearance and contrast ratio, and so on.
[Key wordslBone diseases;Radionuclide Bone image agents; Phosphonat;Single
photon imaging;PET imaging agent
放射性核素骨显像(radionuclide bone imaging)是影像核医学的优势项0和最常用的检査方法之一。经静脉注射的趋骨性显像剂