人血清附睾蛋白4检测在卵巢癌诊断中的价值分析.docx

人血清附睾蛋白4检测在卵巢癌诊断中的价值分析[摘要]目的通�^对卵巢癌、卵巢良性肿瘤、健康人群人附睾蛋白4、CA125检测,探讨HE4在卵巢癌诊断中的应用价值。方法选取赣州市肿瘤医院XX年5月~XX年12月符合入选标准的病例,采用电化学发光检测法对57例卵巢癌患者、49例卵巢良性肿瘤患者及100例体检健康者的血清HE4水平进行检测,并与CA125的检测数值结果进行比较分析。结果卵巢癌组的血清HE4水平为pmol/L,显著高于卵巢良性肿瘤组的pmol/L和对照组的pmol/L,差异均有统计学意义。HE4诊断卵巢癌的敏感度和特异度较高,不同方法联合HE4及CA125检测卵巢癌的敏感度和特异度可分别达到%和%,较单一肿瘤标志物的检测更具优势。结论血清中HE4水平对卵巢癌具有较高的诊断价值,是诊断卵巢癌新的血清肿瘤标志物之一。[关键词]人附睾蛋白4;卵巢癌;肿瘤标志物;诊断[中图分类号][文献标识码]A[文章编号]1674-47211-0126-03 Valueanalysisofserumhumanepididymisprotein4inthediagnosisofovariancancer LIULian-bin1ZHOUMao-hua1YUYing2XUELing1LIRong3WANGQi2ZHOUXiao-juan1LINWei1 ofClinicalLaboratory,TumorHospitalofGanzhouCityinJiangxiProvince,Ganzhou341000,China;ofGynecology,TumorHospitalofGanzhouCityinJiangxiProvince,Ganzhou341000,China;ofPathology,TumorHospitalofGanzhouCityinJiangxiProvince,Ganzhou341000,China [Abstract]ObjectiveToexploretheapplicationvalueofHE4inthediagnosisofovariancancerbydetectinghumanepididymalprotein4andCA125inovariancancer,benignovariantumorandhealthyFromMayXXtoDecemberXX,thecasesthatconformtothecriteriaforadmissioninTumorHospitalofGanzhouCitywereserumlevelofHE4of57casesofpatientswithovariancancer,49casesofovarianbenigntumorpatientsand100healthypeopleweredetectedbyelectrochemiluminescencedetectionmethod,paredw