丙型肝炎治疗药物研究与设计_毕业设计.doc

丙型肝炎治疗药物研究与设计目录丙型肝炎治疗药物研究与设计………………………………………………………3以生命周期划分HCV治疗药物整理………………………………………4HCV的结构………………...……………………………………………4HCV生命周期………………………………………………………...…5以生命周期划分HCV治疗药物整理…………………………..............6总结和展望………………………...…………………………..……….13基于NS5A抑制剂的创新药物设计………………………………………14前言..........................................................................................................14NS5A靶点...............................................................................................14NS5A抑制剂研究进展...........................................................................15BMS-790052(daclatasvir)研究................................................................20创新药物设计..........................................................................................24参考文献..................................................................................................26TLR-7激动剂研究与设计………………………………………………….29目前已开发的激动剂..............................................................................29咪唑喹啉***(imidazoquinolineamine)类..................................291-取代吡唑啉***(1-SubstitutedPyrazolo(3,4-C)Ring)类......318-氧-去氮嘌呤类/咪唑并吡啶***类............................................328-羟基腺嘌呤(8-Hydroxyadenine)类......................................36扩环8-羟基腺嘌呤类..................................................................57艾沙托立宾(Isatoribine)衍生物类..........................................61BitriazolylAcyclonucleoside类...................................................64三氮唑类(Triazole).................................................................65嘧啶类(Pyrimidine).................................................................668-SubstituedBenzoazepines类....................................................68Aminodiazepine类.......................................................................69未来可能的变动空间..............................................................................70创新药物设计..........................................................................................71参考文献.................................