卒中后抑郁胰岛素样生长因子-1与临床病理因素地关系.doc

卒中后抑郁胰岛素样生长因子-1与临床病理因素的关系景丽英(天门市中医院内一科,湖北天门431700)[摘要]目的研究卒中后抑郁患者血清胰岛素样生长因子-1(IGF-1)与临床病理因素的关系。方法选择脑卒中后抑郁患者为研究对象(PSD组),以同期健康体检的正常人为对照(CON组),比较两者间IGF-1的差异,比较不同临床病理因素中IGF-1的差异。结果PSD组患者血清IGF-±,±,PSD组患者血清IGF-1水平显著高于CON组(P<)。PSD患者血清IGF-1水平在性别、年龄、吸烟史、糖尿病史、脑卒中部位及脑卒中分布中的差异无统计学意义(均P>),在抑郁程度中的差异有统计学意义(P<),抑郁程度越高,PSD患者血清IGF-1水平越高。结论卒中后抑郁患者血清IGF-1与抑郁程度有关,可作为卒中后抑郁病情评估的标志物。[关键词]卒中后抑郁;胰岛素样生长因子-1;临床病理因素Relationshipbetweeninsulin-likegrowthfactor-1andclinicopathologicalfactorsinpoststrokedepressionJingLiying(TianmenShiZhongYiYuanNei1Ke,HubeiTianmen431700)[Abstract]ObjectiveTostudytherelationshipbetweeninsulin-likegrowthfactor-1(IGF-1)(PSDgroup),andhealthynormalsubjectsascontrols(CONgroup)-likegrowthfactor-paredandtherelationshipbetweeninsulin-likegrowthfactor--±±-1inPSDgroupwassignificantlyhigherthaninCONgroup(P<).Thedifferecesofinsulin-likegrowthfactor-1indegreeofdepressionwassignificantly(P<),whiletheywerenotinagender,age,smokingstory,diabetesstory,-1correlateswithdegreeofdepressioninpoststrokedepression,whichcouldactasabiomarkerforpoststrokedepress