丙氨酸谷氨酰胺.doc

ARandomizedTrialofGlutamineandAntioxidantsinCriticallyIllPatients对于重症病人的抗氧化剂和谷氨酰***的随机使用试验DarenHeyland,.,JohnMuscedere,.,,.,DeborahCook,.,GwynneJones,.,MartinAlbert,.,GunnarElke,.,,.,.,,.,,althoughcurrentdataareconflicting重症病人有很大的氧化应激,谷氨酰***和抗氧化剂可以提供很好的治疗效果,尽管这些和最新的数据些矛盾。MethodsInthisblinded2-by-2factorialtrial,werandomlyassigned1223criticallyilladultsin40intensivecareunits(ICUs)inCanada,theUnitedStates,anfailureandwerereceivingmechanicalventilationtoreceivesupple-mentsofglutamine,antioxidants,both,---analysisplan,,我们将1223名重症成年病人随机分配到加拿大,美国和欧洲的40个重症监护室里,这些病人都是因多器官功能衰竭而接受机械通气并且需要提供谷氨酰***,抗氧化剂。补充品是在24小时后进入ICU行静脉注射和伤后提供。主要结果是28天死亡。由于临时研讨工作,。ResultsTherewasatrendtowardincreasedmortalityat28daysamongpatientswhore-paredwiththosewhodidnotreceiveglutamine(%%;adjustedoddsratio,;95%confidenceinterval[CI],;P=).In-