肝动脉硬化.doc

动脉硬化是动脉的一种非炎症性病变,可使动脉管壁增厚、变硬,失去弹性、管腔狭小。而肝硬化是临床常见的慢性进行性肝病,由一种或多种病因长期或反复作用形成的弥漫性肝损害。在我国大多数为肝炎后肝硬化,少部分为酒精性肝硬化和血吸虫性肝硬化。
动脉硬化分为细小动脉硬化,中层动脉硬化和动脉粥样硬化,其中动脉粥样硬化是最常见的,也是心肌梗死和脑梗死的主要病因
Title:Therapeutic silencing of microRNA-33 inhibits the progression of atherosclerosis in Ldlr-/- mice--brief report.
Arterioscler Thromb Vasc Biol. 2013 Aug;33(8):1973-7. doi: .301732. Epub 2013 May 23.
Abstract
OBJECTIVE:
To study the efficacy of anti-miRNA-33 therapy on the progression of atherosclerosis.
APPROACH AND RESULTS:
Ldlr(-/-) mice were injected subcutaneously with PBS, control, or anti-miR-33 oligonucleotides weekly and fed a Western diet for 12 weeks. At the end of treatment, the expression of miR-33 target genes was increased in the liver and aorta, demonstrating effective inhibition of miR-33 function. Interestingly, plasma high-density lipoprotein (HDL)-cholesterol was significantly increased in anti-miR-33-treated mice but only when they were fed a chow diet. However, HDL isolated from anti-miR-33-treated mice showed an increase cholesterol efflux pared with HDL isolated from nontargeting oligonucleotide-treated mice. Analysis of atherosclerosis revealed a significant reduction of plaque size and macrophage content in mice receiving anti-miR-33. In contrast, no differences in collagen content and necrotic areas were observed among the 3 groups.
CONCLUSIONS:
Lon