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Jaundice
Gastroenterology Department,
First Affiliated Hospital of Chongqing Medical University
Bingqiang Zhang
Aims and Demands
1. Grasp the concept of jaundice, clinical manifestation
and points of inquisition
2. Familiar the etiology and mechanism of jaundice
3. Realize normal bilirubin metabolism
Definition:jaundice,or icterus refers to the yellow appearance of the skin,scleral and mucous membranes resulting from an increased bilirubin concentration in the body fluids.
Total bilirubin: -
Conjugated bilirubin:0-,
Unconjugated bilirubin:-.
Liver
Albunin
Heme
Ferroheme
transferase
Bilirubin
Conjugated bilirubin
Kidney
Urobilin
Stercobilinogen
Urobilinogen
Intestines
Albumin
Bilirubin
reductase
Heme
Globin
Hemoglobin
oxidase
Biliverdin
Marrow
Infantility Erythrocyte
Ferroheme Enzyme
15%~20%
Bilirubin
|
Albumin
Erythrocyte
80%~85%
UDP
UDPGA
Bilirubin glucuronolactone
urobilinogen
Enterohepatic circulation
Y/Z protein
cathepsin
Erythrocyte
Normal bilirubin metabolism
Normal bilirubin metabolism
Classification
1. Depending on Etiology
Hemolytic Jaundice
Hepatocellular Jaundice
Cholestatic Jaundice
Congenital jaundice
2. Depending on bilirubin
Unconjungated bilirubing increased jaundice
Conjungated bilirubing increased jaundice
Etiology
hemolytic anemia (thalassemia,hereditary spherocytosis).
acquired hemolytic anemia (autoimmunity hemolytic anemia, hemolytic disease of newborn, posttransfusion hemolytic, Favism).
Mechanism
A large number of erythrocyte destroyed rapidly
Anemia,hypoxia and toxity of erythocyte metabolism products
Jaundice
Haemolytic Jaundice mechanism
Clinical Manifestation
Mild jaundice,light lemon,no skin itch.
Acute hemolytis: fever,chill,headache,vomit,backache,anemia, hemoglobinuria( dark sauce or tea), acute renal failure.
Chronic hemolysis:anemia and splenomegaly.
Laboratory Examination
TB↑,UCB↑,CB normal.
Gastroenterology Department,
First Affiliated Hospital of Chongqing Medical University
Bingqiang Zhang
Aims and Demands
1. Grasp the concept of jaundice, clinical manifestation
and points of inquisition
2. Familiar the etiology and mechanism of jaundice
3. Realize normal bilirubin metabolism
Definition:jaundice,or icterus refers to the yellow appearance of the skin,scleral and mucous membranes resulting from an increased bilirubin concentration in the body fluids.
Total bilirubin: -
Conjugated bilirubin:0-,
Unconjugated bilirubin:-.
Liver
Albunin
Heme
Ferroheme
transferase
Bilirubin
Conjugated bilirubin
Kidney
Urobilin
Stercobilinogen
Urobilinogen
Intestines
Albumin
Bilirubin
reductase
Heme
Globin
Hemoglobin
oxidase
Biliverdin
Marrow
Infantility Erythrocyte
Ferroheme Enzyme
15%~20%
Bilirubin
|
Albumin
Erythrocyte
80%~85%
UDP
UDPGA
Bilirubin glucuronolactone
urobilinogen
Enterohepatic circulation
Y/Z protein
cathepsin
Erythrocyte
Normal bilirubin metabolism
Normal bilirubin metabolism
Classification
1. Depending on Etiology
Hemolytic Jaundice
Hepatocellular Jaundice
Cholestatic Jaundice
Congenital jaundice
2. Depending on bilirubin
Unconjungated bilirubing increased jaundice
Conjungated bilirubing increased jaundice
Etiology
hemolytic anemia (thalassemia,hereditary spherocytosis).
acquired hemolytic anemia (autoimmunity hemolytic anemia, hemolytic disease of newborn, posttransfusion hemolytic, Favism).
Mechanism
A large number of erythrocyte destroyed rapidly
Anemia,hypoxia and toxity of erythocyte metabolism products
Jaundice
Haemolytic Jaundice mechanism
Clinical Manifestation
Mild jaundice,light lemon,no skin itch.
Acute hemolytis: fever,chill,headache,vomit,backache,anemia, hemoglobinuria( dark sauce or tea), acute renal failure.
Chronic hemolysis:anemia and splenomegaly.
Laboratory Examination
TB↑,UCB↑,CB normal.
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