IGF1R和BRCA1在乳腺良恶性肿瘤中表达及其意义.pdf

%,在乳腺癌中的表达与腋窝淋巴结的转移情况、肿瘤大小、病理类型和组
织学分级无关(P 均>);BRCA1 在乳腺纤维腺瘤中的阳性表达率 %,在
乳腺癌中的阳性表达率 %,乳腺癌中腋窝有淋巴结转移的表达率明显低于无
淋巴结转移的表达率(P<),并随着肿瘤分级的升高有逐渐下降趋势,其中
Ⅰ级和Ⅲ级、Ⅱ级和Ⅲ级间的差异显著(P<),Ⅰ级与Ⅱ级间无差异
(P=),BRCA1 的表达与肿瘤的组织学类型、肿块大小无关(均 P>);
IGF1R 和 BRCA1 在乳腺癌中的表达无相关性(χ²= P>)。
结论
由此推断,IGF1R 和 BRCA1 在乳腺癌中的发生发展过程中有重要的作用,它
们有可能成为临床对乳腺癌诊断、靶基因治疗和判断预后的分子生物学指标;另
外 IGF1R 和 BRCA1 在乳腺癌的发生中可能是两个独立事件。

关键词:乳腺肿瘤;胰岛素生长因子-1 受体;乳腺癌易感基因-1;免疫组织化
学
The expression and significance of BRCA1 and IGF1R in
breast malignant and benign tumors
Abstract
Background and Objective
Breast cancer is one of the mon malignancies among
,its etiology has not been fully ,cumulative
experimental results suggest that breast cancer susceptibility gene
one(BRCA1) and the insulin-like growth factor-Ⅰ receptor(IGF1R) play a
critical role in breast cancer development and is a tumor
suppressor gene,which normally function as a negative regulator of the cell
cycle ,DNA repair and may be an active inhibitor of neoplastic
alteration of BRCA1 is well known to cause familial
breast cancer. Mutation of the BRCA1 gene has been demonstrated in 80% of
familial breast somatic mutation of the BRCA1 gene are rare
in sporadic breast cancers,a high incidence of reduced the expression of
BRCA1 protein in sporadic breast cancers has been ,in
turn,suggests that the BRCA1 gene might have a tumor suppressor function
also in sporadic breast insulin-like growth factor-Ⅰreceptor
is a tyrosine kinase,transmembrane receptor expressed in most body tissues
and required for normal growth of -1R can mediate signal
transduction by the insulin-like growth factor system and play an important
role in transformation is highly overexpressed in most malignant
tissues,including colon cancer,breast cancer,liver cancer,and so
insulin-l