孟德尔随机化分析原理解析MendelianRandomisationstudySNPs25OHDAsthmaChildhoodasthmaAtopicdermatitisIgEConfounders(BMI,Smoking)Pleiotropy(eosinophils)StandardizedplaninMendelianrandomisationstudyExtractinterestingSNPsExtractdataofcasesandcontrolsTwo-sampleMRPotentialproblemsandlimitationsofMendelianrandomisationstudyValidateSNPsExtractinterestingSNPsPvalue<5×10−,CanadianMulticentreOsteoporosisStudy(CaMos)(UKBiobank)(icInvestigationofAnthropometricTraits),HeightExtractdataofcasesandcontrolsUKBiobankAsthma,hildrenAsthma(GABRIELconsortium)Atopicdermatitis(EAGLEEczemaConsortium)IgElevels(GABRIELconsortium)icsandLifecourseEpidemiology(EAGLE)******@HavethedetailinformationofinterestedSNPsincasesandcontrolsTwo-,icvariantsandAsthma,Childhoodasthma,Atopicdermatitis,
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