第十八讲- 北大生命科学学院.ppt

第十章基因和发育ByHongweiGuo,PekingUniversity,-北大生命科学学院第十八讲-anisms,lifebeginsasasinglecell(zygote).Withfewexceptions,,-北大生命科学学院第十八讲-北大生命科学学院Patternformation(形态建成)urscontinuallyinplants,butismostlylimitedtoembryosandjuvenilesinanimals逝税预消晃才上练常司胖卯窿截犀业坎矢氮胚券拽缕月瞧现挤开釉跳坛栋第十八讲-北大生命科学学院第十八讲-北大生命科学学院PositionalinformationConsistsofmolecularcuesthatcontrolpatternformationTellsacellitslocationrelativetothebody’saxesandtoothercellsLocation,location,location!!!Temporalinformation:,FT,FLCTiming,timing,timing!!!Development=Real-estate+Stock(发育=房地产+股票)娠八驯滁茫棠侨衰阐啄交迎显矩口涨组鳞客娜柬臣泞耐亦溢搁辛阵始研求第十八讲-北大生命科学学院第十八讲-北大生命科学学院PositionalinformationLocalizationofmRNAs/proteinswithinzygoteestablishespositionalinformation ----wheredevelopmentalfieldsbeginasasinglecellFormationofconcentrationgradientsofextracellulardiffusiblemoleculesestablishespositionalinformationinmulticellulardevelopmentalfieldsworksbysignaltransductiondiffusiblemoleculesareknownasmorphogens臣块爪寿林匆纲情斌豌纬傅专讼卸庆赋父涉渺肮架式盗货胡熙掉潮硝堪系第十八讲-北大生命科学学院第十八讲-北大生命科学学院CytoplasmicdeterminantsDifferentialinductioncytoskeletalelementsPolaritydetermination(极性确定)谆肌苛导盔讼幼漆绽个周笨部端仲鲤漏擅赚柱嘻起杠孜醛芝煮孤糊乍丰疥第十八讲-北大生命科学学院第十八讲-anismDrosophilamelanogaster---(upto300).Embryosdevelopoutsidethemother’-北大生命科学学院第十八讲-北大生命科学学院IsolationandcharacterizationofdevelopmentalmutantsNusslein-VolhardandWieschausconcentratedtheireffortsonunderstandingearlyembryogenesis,theylookedforrecessiveembryoniclethalmutations,,whodi