Survivin、雌激素受体、孕激素受体在子宫内膜癌中表达的意义.doc

Survivin、雌激素受体、孕激素受体在子宫内膜癌中表达的意义
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作者:刘曼华陶潜,郑艳莉,鲁晓燕,杨其昌,沈屹
【摘要】目的:结合临床病理学特征探讨Survivin、ER、PR在子宫内膜癌组织中表达的意义。方法:应用免疫组化SP法检测60例子宫内膜癌、34例癌旁组织标本中Survivin、ER、PR蛋白的表达情况。结果:(1)%,%(P<);(2)ER、%、%,%,%(P<);(3)随着晚手术病理分期、组织学低分化、深肌层浸润及淋巴结转移Survivin表达增高,而PR却呈低表达(),ER表达与组织学分级、肌层浸润程度有关();(4)Survivin与ER、PR在子宫内膜癌中的表达均呈负相关(r=-,;r=-,)。结论:Survivin、ER、PR在子宫内膜腺癌的发生、发展过程中可能发挥着重要作用,ER、PR在癌组织的变化提示癌细胞丧失了原来细胞的功能;联合检测Survivin、ER、PR在子宫内膜癌中的表达有助于协助诊治并判断预后。
【关键词】子宫内膜癌;免疫组织化学法;Survivin蛋白;雌激素受体;孕激素受体
[Abstract] Objective: Combined with the pathological characteristics,to study the expression of survivin, estrogen receptor(ER)and progesterone receptor(PR) in human endometrial carcinomas(EC). Method: Archived tissue samples of 60 EC and 34 paracarcinoma were selected and immunohistochemically analyzed for survivin、ER and PR expression. Results: The positive rate of survivin was significantly higher in EC than in paracarcinoma (65% vs %)(P<), but ER(50% vs %) and PR(% vs %) reverse were(P<).Both survivin and PR expressions were associated wi th clinical pathological characteristics of endometrial carcinoma such as surgical-pathological stage,histological grade,myometrial invasion , lymph node metastasis. (). ER expressi