hpv感染的演变过程.ppt

hpv感染的演变过程已知hr-HPV感染子宫颈鳞状上皮基底旁层细胞,以基因附加体或插入整合形式存在和表达。从而导致宿主细胞基因不稳定,细胞表型改变和无限增生。HowinducesHPVcervicaldysplasiaandcancer?HPVinvadesbasalcells&,ellsmoveupandreachsurfaceAfter?2-4weeksEpithelialcellsmaturate&movein7- 1 2 3 4 5 6 7 MonthsCIN-3CIN-2CIN-1nrm/reacthrHPV80%ofhrHPVinfectedwomendonotdevelopCIN0 1 2 3 4 5 6 7 MonthsCIN-3CIN-2CIN-1nrm/reacthrHPV0 1 2 3 4 5 6 7 MonthsCIN-3CIN-2CIN-1nrm/reacthrHPV0 1 2 3 4 5 6 7 MonthsCIN-3CIN-2CIN-1nrm/reacthrHPV0 1 2 3 4 5 6 7 MonthsCIN-3CIN-2CIN-1nrm/reacthrHPVBiopsyCIN1-2-3grade:AmicroscopicimageofaCINlesionbiopsyisjustONEsnapshot(”photo”)ofadynamicprocess(”film”)ofmanyweeks/months出现细胞DNA倍体异常情况:肿瘤:基因改变HPV感染:DNA病毒整合放疗:细胞异常增生和死亡图10-1图10-2尿液细胞学检查