肿瘤细胞来源的外泌体对肿瘤恶性进展和化疗抵抗的影响.doc


肿瘤细胞来源的外泌体对肿瘤恶性进展和
化疗抵抗的影响#




,李桂源

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(1. 中南大学肿瘤研究所,卫生部癌变原理重点实验室,教育部癌变与侵袭原理重点实验
室,长沙 410078;
2. 湖南省颅底外科与神经肿瘤临床医疗技术研究中心,长沙 410078)
摘要:外泌体是细胞分泌的一种纳米级囊泡结构。作为一类重要的细胞间通信分子,可通过多种方式发挥
,可以在人体中发挥调节作用。目前在多种类型
的细胞中都发现了外泌体的存在,而肿瘤细胞来源的外泌体因其具有的独特成分可通过影响微环境,激发
相关信号通路等方式参与肿瘤的恶性进展,使肿瘤在治疗过程中产生化疗抵抗。同时,肿瘤细胞来源的外
泌体中含有的蛋白质,脂质,RNA 等成分不仅可用于疾病的临床诊断,也可为肿瘤的个体化治疗提供新的
思路。
关键词:外泌体;化疗抵抗; 肿瘤微环境; miRNA; 免疫耐受
中图分类号:Q-1; Q-3; Q75 ;R73
The Effect of Tumor Cells-derived exosome on Tumor
Malignant Progression and Chemoresistance
LIU Changhong1,2,3,4,5, WU Minghua1,2,3,4,5, LI Guiyuan1,2,3
(1. Cancer Research Institute, Central South University;
2. Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education;
3. Key Laboratory of Carcinogenesis of Ministry of Health Center, Changsha 410078, China;
4. 2) The Center for Skull Base Surgery and Neuro-oncology of Hunan Province, Changsha
410078, China;
5. The Center for Skull Base Surgery and Neuro-oncology of Hunan Province, Changsha 410078,
China)
Abstract:
Exosomes are nano-sized vesicles which are secreted by cells, The exosomes are also
a kind of important munication molecules and exert various biological effect. The studies
suggested that the exosome contains many kinds of ponents that play a regulatory
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role in physilology condition. Althou