老年患者超说明书应用盐酸氨溴索注射液分析..doc

,张鹏1*,曾蘩友2,王晓雯1,左燕1(,西安 710068;,旬阳 725700摘要:目的通过调查医院老年住院患者盐酸氨溴索注射液超说明书规定用药的现状,发现存在问题,并进行合理性分析,为临床合理使用盐酸氨溴索注射液以及药师评判其处方的合理性提供参考和依据。方法采用回顾性调查方法,收集已出院的239例使用盐酸氨溴索注射液患者的病例,对超说明书用药患者年龄、使用剂量、用药诊断、给药方式及频次、疗程等指标进行统计分析。结果在调查的239例使用盐酸氨溴索注射液的患者中,超说明书用药230例,%;超说明书用药诊断主要集中在慢性阻塞性肺疾病及肺间质性疾病,%%。结论盐酸氨溴索注射液超说明书用药在老年住院患者呼吸系统疾病的治疗中普遍存在,超剂量、超适应证使用现象突出,其合理性、安全性和确定性均值得商榷。关键词:盐酸氨溴索注射液;超适应证;超剂量;慢性阻塞性肺疾病;间质性肺疾病doi:.1004-: 文献标志码:A 文章编号:1004-2407(201403-0305-04Analysis of off-label drug use of Ambroxol Hydrochloride Injections in hospitalizedelderly patientsLI Jing1,ZHANG Peng1*,ZENG Fanyou2,WANG Xiaowen1,ZUO Yan1(Department of Pharmacy,the People′s Hospital ofShaanxi Province,Xi′an 710068,China; County Hospital of Shaanxi Province,Xunyang 725700,ChinaAbstract:Objective To investigate the off-label drug use of Ambroxol Hydrochloride Injections in hospitalized elderly patients inour to provide the reference and basis for its rational By using the method of retrospective survey,239cases were investigated in terms of age,dose of drug,cure,medicine diagnosis,and expense, The ratio of off-la-bel use cases was %.The off-label drug use was mainly in chronic obstructive pulmonary disease and interstitial lung dis-ease,occupied %and % Off-label use of Ambroxol Hydrochloride Injections generally existsin the treatment of respiratory diseases amonghospitalized elderly words:Ambroxol Hydrochloride Injections;out-off label indication;overdose;chronic obstructive pulmonary disease;intersti-tial lung disease作者简介:李静,女,主管药师*通信作者:张鹏,男,副主任药师盐酸氨溴索(ambroxol hydrochloride又名溴环己***醇,是溴己新在体内的活性代谢产物,是传统的黏液溶解剂及排痰药的代表。除可使痰中的黏多糖蛋白纤维断裂、促进黏痰溶解、增进支气管黏膜纤毛运动、促进痰液排出的作用外,还能促进肺表面活性物质的分泌及气道液体分泌,最终改善通气功能和呼吸困难情况[1]。因其毒性小,耐受性及安全性好,在各级医院的使用非常普遍。临床应用剂量的选择跨度较大、药理作用机制多元、给药途径多样,造成临床使用中超过说明书规定剂量与适应证用药的现象屡见不鲜[2-3]。医院药师调剂处方之前,须对医师处方进