老年期痴呆患者脑血管储备功能的测定..doc

老年期痴呆患者脑血管储备功能的测定        摘要: 目的评价DiamoxSPECT脑血流(CBF)负荷显像对于老年期痴呆的诊断价值。方法采用Diamox药物负荷99mTc-ECDSPECT核素显像技术对Alzheimer型痴呆(DAT)患者10例、血管性痴呆(VD)患者20例、正常对照者15例进行脑血管储备功能测定。结果安静状态下,两痴呆组平均脑血流量均显著低于对照组(P<),不同程度VD组间脑血流无统计学意义。Diamox负荷后VD组血流增加值(△CBF)显著减少,并且各VD组间出现显著差异。而DAT组变化不明显。结论 Diamox药物负荷SPECT脑灌注显像技术是一种较为完善的脑功能检测手段,它有助于早期发现脑血管储备功能受损的代偿期患者,判断病情程度及鉴别老年期痴呆的不同类型。关键词: Alzheimer型老年痴呆; 血管性痴呆; Diamox; 脑血管储备功能; SPECT 中分类号:R742 文献标识码:A 文章编号:1003-2754(2000)04-0218-03AstudyoncerebrovascularreservecapacityofpatientswithseniledementiaXUJing ZHENGLi-sha ZHANGYan-jun.(DepartmentofNeurology,TheFirstAffiliatedHospitalofDalianMedicalCollege,Dalian116011,China) Abstract: Objective ToevaluatethediagnosticvalueofDiamoxstressSPECTcerebralbloodflow(CBF) Cerebrovascularreservecapcity(CRC)inpatientswithseniledementiawasanalyzedbypre-andpost-DiamoxstressSPECTusing99m Tc-:dementiaofAlzheimer,stype(DAT)group(n=10)andvasculardementia(VD)group(n=20),andthecontrolgroupconsistedof15age- TherestmeanCBF(mCBF)ofDATandVDgroupwasmuchlowerthanthatofthecontrols(P<).ThedifferencesofrestCBFamongthesub-,ThedegreeofCBFincrease(△CBF)inVDgroupwasreducedremarkably,-groupsinVDatpost- ,evenintheearlystage,andcouldbeusefulinjudgingtheseverityofdiseaseandindifferentiatingthevariedtypesofseniledementia. Keywords: DementiaofAlzheimer,stype; Vasculardementia; Diamox; CerebrovascularReservecapacity(CRC); SPECT▲